Stuart MacNeill

2024

Biogenesis, inheritance and 3D ultrastructure of the microsporidian mitosome

Hacker, C., Sendra, K., Keisham, P. D., Filipescu, T., Lucocq, J., Salimi, F., Ferguson, S. G. A., Bhella, D., MacNeill, S., Embley, M. & Lucocq, J. M., 1 Jan 2024, In: Life Science Alliance. 7, 1, 23 p., e202201635.

Research output: Contribution to journal › Article › peer-review

Open Access

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2023

Canonical binding of Chaetomium thermophilum DNA polymerase δ/ζ subunit PolD3 and flap endonuclease Fen1 to PCNA

Alphey, M. S., Wolford, C. & MacNeill, S., 18 Dec 2023, In: Frontiers in Molecular Biosciences. 10, 9 p., 1320648.

Research output: Contribution to journal › Article › peer-review

Open Access

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2022

Non‐canonical binding of the Chaetomium thermophilum PolD4 N‐terminal PIP motif to PCNA involves Q‐pocket and compact 2‐fork plug interactions but no 3₁₀ helix

Yang, D., Alphey, M. S. & MacNeill, S., 22 Aug 2022, (E-pub ahead of print) In: FEBS Journal. Early View, 14 p., 16590.

Research output: Contribution to journal › Article › peer-review

Open Access

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2021

Remote homology detection identifies a eukaryotic RPA DBD-C-like DNA binding domain as a conserved feature of archaeal Rpa1-like proteins

MacNeill, S., 20 Jul 2021, In: Frontiers in Molecular Biosciences. 8, 8 p., 675229.

Research output: Contribution to journal › Article › peer-review

Open Access

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2019

Unexpected insertion of carrier DNA sequences into the fission yeast genome during CRISPR–Cas9 mediated gene deletion

Longmuir, S., Akhtar, N. & MacNeill, S. A., 29 Mar 2019, In: BMC Research Notes. 12, 5 p., 191.

Research output: Contribution to journal › Article › peer-review

Open Access

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2018

Branched late-steps of the cytosolic iron-sulphur cluster assembly machinery of Trypanosoma brucei

Tonini, M. L., Peña-Diaz, P., Haindrich, A. C., Basu, S., Kriegová, E., Pierik, A. J., Lill, R., MacNeill, S. A., Smith, T. K. & Lukeš, J., 22 Oct 2018, In: PLoS Pathogens. 14, 10, 31 p., e1007326.

Research output: Contribution to journal › Article › peer-review

Open Access

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Insights into the evolutionary conserved regulation of Rio ATPase activity

Knüppel, R., Christensen, R., Gray, F. C., Esser, D., Strauss, D., Medenbach, J., Siebers, B., MacNeill, S. A., LaRonde, N. & Ferreira-Cerca, S., 16 Feb 2018, In: Nucleic Acids Research. 46, 3, p. 1441-1456 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Screening of the MMV and GSK open access chemical boxes using a viability assay developed against the kinetoplastid Crithidia fasciculata

Kipandula, W., Young, S. A., MacNeill, S. A. & Smith, T. K., Jun 2018, In: Molecular and Biochemical Parasitology. 222, p. 61-69 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Tandem affinity purification of exosome and replication factor C complexes from the non-human infectious kinetoplastid parasite Crithidia fasciculata

Kipandula, W., Smith, T. K. & MacNeill, S. A., Oct 2017, In: Molecular and Biochemical Parasitology. 217, p. 19-22 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

A novel archaeal DNA repair factor that acts with the UvrABC system to repair mitomycin C-induced DNA damage in a PCNA-dependent manner

Giroux, X. & MacNeill, S., 22 Dec 2015, In: Molecular Microbiology. 99, 1, p. 1-14

Research output: Contribution to journal › Article › peer-review

Open Access

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Inhibiting NAD⁺-dependent DNA ligase activity with 2-(cyclopentyloxy)-5'-deoxyadenosine (CPOdA) offers a new tool for DNA replication and repair studies in the model archaeon Haloferax volcanii

Giroux, X. & MacNeill, S., 2015, In: FEMS Microbiology Letters. 362, 21, 5 p., fnv181.

Research output: Contribution to journal › Article › peer-review

Open Access

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Molecular genetic methods to study DNA replication protein function in Haloferax volcanii, a model archaeal organism.

Giroux, X. & MacNeill, S., 2015, In: Methods in Molecular Biology. 1300, p. 187-218 31 p.

Research output: Contribution to journal › Article › peer-review

2014

Identification of a candidate Rad1 subunit for the kinetoplastid 9-1-1 (Rad9-Hus1-Rad1) complex

MacNeill, S., 19 Dec 2014, In: Biology. 3, 4, p. 922-927 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The haloarchaeal MCM proteins: bioinformatic analysis and targeted mutagenesis of the β7-β8 and β9-β10 hairpin loops and conserved zinc binding domain cysteines

Kristensen, T. P., Cherian, R. M., Gray, F. C. & MacNeill, S., 26 Mar 2014, In: Frontiers in Microbiology. 5, 123.

Research output: Contribution to journal › Article › peer-review

Open Access

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2012

Conditional inactivation of replication proteins in fission yeast using hormone-binding domains

Pai, C.-C., Schnick, J., MacNeill, S. & Kearsey, S., 2012, In: Methods.

Research output: Contribution to journal › Article › peer-review

Identification of essential and non-essential single-stranded DNA-binding proteins in a model archaeal organism

Skowyra, A. & MacNeill, S., 1 Feb 2012, In: Nucleic Acids Research. 40, 3, p. 1077-1090 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen

Salguero, I., Guarino, E., Shepherd, M. E. A., Deegan, T. D., Havens, C. G., MacNeill, S. A., Walter, J. C. & Kearsey, S. E., 24 Apr 2012, In: Current Biology. 22, 8, p. 720-726 7 p.

Research output: Contribution to journal › Article › peer-review

2011

Protein-protein interactions in the archaeal core replisome

MacNeill, S. A., Feb 2011, In: Biochemical Society Transactions. 39, p. 163-168 6 p.

Research output: Contribution to journal › Article › peer-review

Purification and functional inactivation of the fission yeast MCM^MCM-BP complex

Li, J.-J., Schnick, J., Hayles, J. & MacNeill, S. A., 15 Dec 2011, In: FEBS Letters. 585, 24, p. 3850-3855 6 p.

Research output: Contribution to journal › Article › peer-review

2010

The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain

Swiatek, A. & MacNeill, S. A., 12 Apr 2010, In: Biology Direct. 5, 1, p. 17 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2009

Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis

Garcia, J., Baranovskiy, A., Knatko, E., Gray, F., Tahirov, T. & MacNeill, S. A., 17 Aug 2009, In: BMC Molecular Biology. 10, 13 p., 82.

Research output: Contribution to journal › Article › peer-review

Open Access

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GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast

Pai, C. C., Garcia, I., Wang, S. W., Cotterill, S., MacNeill, S. A. & Kearsey, S. E., 15 Feb 2009, In: Molecular Biology of the Cell. 20, 4, p. 1213-1222 10 p.

Research output: Contribution to journal › Article › peer-review

Inactivating pentapeptide insertions in the fission yeast replication factor C subunit Rfc2 cluster near the ATP-binding site and arginine finger motif

Gray, F., Whitehead, K. & MacNeill, S. A., Sept 2009, In: FEBS Journal. 276, 17, p. 4803-4813 11 p.

Research output: Contribution to journal › Article › peer-review

MCM-GINS and MCM-MCM interactions in vivo visualised by bimolecular fluorescence complementation in fission yeast

Akman, G. & MacNeill, S. A., 19 Feb 2009, In: BMC Cell Biology. 10, 7 p., 12.

Research output: Contribution to journal › Article › peer-review

Open Access

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Structural insights into the adaptation of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii to a high-salt environment

Morgunova, E., Gray, F., MacNeill, S. A. & Ladenstein, R., Oct 2009, In: Acta Crystallographica. Section D, Biological crystallography. 65, p. 1081-1088 8 p.

Research output: Contribution to journal › Article › peer-review

2008

Rapid regulation of protein activity in fission yeast

Boe, C. A., Garcia, I., Pai, C.-C., Sharom, J. R., Skjolberg, H. C., Boye, E., Kearsey, S., MacNeill, S. A., Tyers, M. D. & Grallert, B., 5 May 2008, In: BMC Cell Biology. 9, 11 p., 23.

Research output: Contribution to journal › Article › peer-review

Open Access

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2006

ATP-dependent and NAD⁺-dependent DNA ligases share an essential function in the halophilic archaeon Haloferax volcanii

Zhao, A., Gray, F. & MacNeill, S. A., Feb 2006, In: Molecular Microbiology. 59, 3, p. 743-752 10 p.

Research output: Contribution to journal › Article › peer-review

Biochemical characterisation of LigN, an NAD⁺-dependent DNA ligase from the halophilic euryarchaeon Haloferax volcanii that displays maximal in vitro activity at high salt concentrations

Poidevin, L. & MacNeill, S. A., Nov 2006, In: BMC Molecular Biology. 7

Research output: Contribution to journal › Article › peer-review

2005

Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast

Kim, J., Robertson, K., Mylonas, K., Gray, F., Charapitsa, I. & MacNeill, S. A., 2005, In: Nucleic Acids Research. 33, 13, p. 4078-4089 12 p.

Research output: Contribution to journal › Article › peer-review

2004

Functional analysis of subcellular localization and protein-protein interaction sequences in the essential DNA ligase I protein of fission yeast

Martin, I. & MacNeill, S. A., Jan 2004, In: Nucleic Acids Research. 32, 2, p. 632-642 11 p.

Research output: Contribution to journal › Article › peer-review

Genetic and biochemical analyses of Pfh1 DNA helicase function in fission yeast

Ryu, G., Tanaka, H., Kim, D., Kim, J., Bae, S., Kwon, Y., Rhee, J., MacNeill, S. A. & Seo, Y., Aug 2004, In: Nucleic Acids Research. 32, 14, p. 4205-4216 12 p.

Research output: Contribution to journal › Article › peer-review

Genetics of lagging strand DNA synthesis and maturation in fission yeast: suppression analysis links the Dna2-Cdc24 complex to DNA polymerase delta

Tanaka, H., Ryu, G., Seo, Y. & MacNeill, S. A., 2004, In: Nucleic Acids Research. 32, 21, p. 6367-6377 11 p.

Research output: Contribution to journal › Article › peer-review

Mapping and mutation of the conserved DNA polymerase interaction motif (DPIM) located in the C-terminal domain of fission yeast DNA polymerase delta subunit Cdc27

Gray, F., Pohler, J., Warbrick, E. & MacNeill, S. A., Dec 2004, In: BMC Molecular Biology. 5, 21.

Research output: Contribution to journal › Article › peer-review

The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit

Garcia, J., Ciufo, L., Yang, X., Kearsey, S. & MacNeill, S. A., Jun 2004, In: Nucleic Acids Research. 32, 10, p. 3005-3016 12 p.

Research output: Contribution to journal › Article › peer-review

2002

The fission yeast pfh1 gene encodes an essential 5' to 3' DNA helicase required for the completion of S-phase

Tanaka, H., Ryu, G., Seo, Y., Tanaka, K., Okayama, H., MacNeill, S. A. & Yuasa, Y., 1 Nov 2002, In: Nucleic Acids Research. 30, 21, p. 4728-4739 12 p.

Research output: Contribution to journal › Article › peer-review

The influence of the cdc27 subunit on the properties of the Schizosaccharomyces pombe DNA polymerase delta

Bermudez, V., MacNeill, S. A., Tappin, I. & Hurwitz, J., 27 Sept 2002, In: Journal of Biological Chemistry. 277, 39, p. 36853-36862 10 p.

Research output: Contribution to journal › Article › peer-review

2001

DNA replication: Partners in the Okazaki two-step

MacNeill, S. A., 16 Oct 2001, In: Current Biology. 11, 20, p. R842-R844 3 p.

Research output: Contribution to journal › Article › peer-review

2000

Essential interaction between the fission yeast DNA polymerase delta subunit Cdc27 and Pcn1 (PCNA) mediated through a C-terminal p21^Cip1-like PCNA binding motif

Reynolds, N., Warbrick, E., Fantes, P. & MacNeill, S. A., 1 Mar 2000, In: EMBO Journal. 19, 5, p. 1108-1118 11 p.

Research output: Contribution to journal › Article › peer-review

Genetic analyses of Schizosaccharomyces pombe dna2⁺ reveal that Dna2 plays an essential role in Okazaki fragment metabolism

Kang, H., Choi, E., Bae, S., Lee, K., Gim, B., Kim, H., Park, C., MacNeill, S. A. & Seo, Y., Jul 2000, In: Genetics. 155, 3, p. 1055-1067 13 p.

Research output: Contribution to journal › Article › peer-review

The Schizosaccharomyces pombe rfc3⁺ gene encodes a homologue of the human hRFC36 and Saccharomyces cerevisiae Rfc3 subunits of replication factor C

Gray, F. & MacNeill, S. A., Mar 2000, In: Current Genetics. 37, 3, p. 159-167 9 p.

Research output: Contribution to journal › Article › peer-review

1999

A key role for replication factor C in DNA replication checkpoint function in fission yeast

Reynolds, N., Fantes, P. & MacNeill, S. A., 15 Jan 1999, In: Nucleic Acids Research. 27, 2, p. 462-469 8 p.

Research output: Contribution to journal › Article › peer-review

Characterisation of XlCdc1, a Xenopus homologue of the small (PolD2) subunit of DNA polymerase delta; identification of ten conserved regions I-X based on protein sequence comparisons across ten eukaryotic species

Reynolds, N. & MacNeill, S. A., 1 Apr 1999, In: Gene. 230, 1, p. 15-22 8 p.

Research output: Contribution to journal › Article › peer-review

1998

Cdm1, the smallest subunit of DNA polymerase delta in the fission yeast Schizosaccharomyces pombe, is non-essential for growth and division

Reynolds, N., Watt, A., Fantes, P. & MacNeill, S. A., Oct 1998, In: Current Genetics. 34, 4, p. 250-258 9 p.

Research output: Contribution to journal › Article › peer-review

1997

DNA polymerase delta isolated from Schizosaccharomyces pombe contains five subunits

Zuo, S., Gibbs, E., Kelman, Z., Wang, T., ODonnell, M., MacNeill, S. A. & Hurwitz, J., 14 Oct 1997, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 21, p. 11244-11249 6 p.

Research output: Contribution to journal › Article › peer-review

Genetic and physiological analysis of DNA replication in fission yeast

MacNeill, S. A. & Fantes, P., 1997, In: Methods In Enzymology. 283, p. 440-459 20 p.

Research output: Contribution to journal › Article › peer-review

1996

The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27

MacNeill, S. A., Moreno, S., Reynolds, N., Nurse, P. & Fantes, P., 2 Sept 1996, In: EMBO Journal. 15, 17, p. 4613-4628 16 p.

Research output: Contribution to journal › Article › peer-review

1995

Meiosis: New roles for RNA in fission yeast

MacNeill, S. & Fantes, P., 1 Jan 1995, In: Current Biology. 5, 1, p. 4-6 3 p.

Research output: Contribution to journal › Article › peer-review

1993

Genetic analysis of human p34^cdc2 function in fission yeast

MacNeill, S. A. & Nurse, P., Sept 1993, In: Molecular and General Genetics. 240, 3, p. 315-322 8 p.

Research output: Contribution to journal › Article › peer-review

Mutational analysis of the fission yeast p34^cdc2 protein kinase gene

MacNeill, S. A. & Nurse, P., Jan 1993, In: Molecular and General Genetics. 236, 2-3, p. 415-426 12 p.

Research output: Contribution to journal › Article › peer-review

1992

Cold-sensitive mutants of p34^cdc2 that suppress a mitotic catastrophe phenotype in fission yeast

AYSCOUGH, K., HAYLES, J., MacNeill, S. A. & NURSE, P., Apr 1992, In: Molecular and General Genetics. 232, 3, p. 344-350 7 p.

Research output: Contribution to journal › Article › peer-review

Stuart MacNeill

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