Stephen Henry Gillespie

2018

OMNIgene.SPUTUM suppresses contaminants whilst maintaining Mycobacterium tuberculosis viability and obviates cold-chain transport

Azam, K., Cadir, N., Madeira, C., Gillespie, S. H. & Sabiiti, W., 16 Feb 2018, In: ERJ Open Research. 4, 8 p., 00074-2017.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Phenotypic changes on Mycobacterium tuberculosis-specific CD4 T cells as surrogate markers for tuberculosis treatment efficacy

Ahmed, M. I. M., Ntinginya, N. E., Kibiki, G., Mtafya, B. A., Semvua, H., Mpagama, S., Mtabho, C., Saathoff, E., Held, K., Loose, R., Kroidl, I., Chachage, M., Both, U. V., Haule, A., Mekota, A.-M., Boeree, M. J., Gillespie, S. H., Hoelscher, M., Heinrich, N. & Geldmacher, C. & 1 others, Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA), 28 Sept 2018, In: Frontiers in Immunology. 9, 13 p., 2247.

Research output: Contribution to journal › Article › peer-review

Open Access

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Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis

Murthy, S. E., Chatterjee, F., Crook, A., Dawson, R., Mendel, C., Murphy, M. E., Murray, S. R., Nunn, A. J., Phillips, P. P. J., Singh, K. P., McHugh, T. D., Gillespie, S. H. & REMoxTB Consortium, 21 May 2018, In: BMC Medicine. 16, 11 p., 73.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Pseudomonas aeruginosa intensive care unit outbreak: winnowing of transmissions with molecular and genomic typing

Parcell, B. J., Oravcova, K., Pinheiro, M., Holden, M. T. G., Phillips, G., Turton, J. F. & Gillespie, S. H., Mar 2018, In: Journal of Hospital Infection. 98, 3, p. 282-288 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

System, devices and methods using an integrated sphere light collector

Hammond, R. J. H. (Inventor), Gillespie, S. H. (Inventor) & Giardini, M. E. (Inventor), 1 Feb 2018

Research output: Patent

The impact of repeated NALC/NaOH- decontamination on the performance of Xpert MTB/RIF assay

Rachow, A., Saathoff, E., Mtafya, B., Mapamba, D., Mangu, C., Rojas-Ponce, G., Ntinginya, N. E., Boeree, M., Heinrich, N., Gillespie, S. H., Hoelscher, M. & PanACEA Consortium, 4 Apr 2018, (E-pub ahead of print) In: Tuberculosis. In press

Research output: Contribution to journal › Article › peer-review

Open Access

File

The potential for treatment shortening with higher rifampicin doses: relating drug exposure to treatment response in patients with pulmonary tuberculosis

Svensson, E. M., Svensson, R. J., Te Brake, L. H. M., Boeree, M. J., Heinrich, N., Konsten, S., Churchyard, G., Dawson, R., Diacon, A. H., Kibiki, G. S., Minja, L. T., Ntingiya, N. E., Sanne, I., Gillespie, S. H., Hoelscher, M., Phillips, P. P. J., Simonsson, U. S. H. & Aarnoutse, R., 18 Jun 2018, In: Clinical Infectious Diseases. 67, 1, p. 34-41 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Toxicity associated with tuberculosis chemotherapy in the REMoxTB study

Tweed, C. D., Crook, A. M., Amukoye, E. I., Dawson, R., Diacon, A. H., Hanekom, M., McHugh, T. D., Mendel, C. M., Meredith, S. K., Murphy, M. E., Murthy, S. E., Nunn, A. J., Phillips, P. P. J., Singh, K. P., Spigelman, M., Wills, G. H. & Gillespie, S. H., 11 Jul 2018, In: BMC Infectious Diseases. 18, 11 p., 317.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Using RT qPCR for quantifying Mycobacteria marinum from in vitro and in vivo samples

Xaio, H. & Gillespie, S. H., 2018, Antibiotic Resistance Protocols. Gillespie, S. (ed.). New York, NY: Humana Press/Springer, p. 137-145 9 p. (Methods in Molecular Biology; vol. 1736).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Open Access

File

2017

A comparison of liquid and solid culture for determining relapse and durable cure in phase III TB trials for new regimens

Phillips, P. P. J., Mendel, C. M., Nunn, A. J., McHugh, T. D., Crook, A. M., Hunt, R., Bateson, A. & Gillespie, S. H., 24 Nov 2017, In: BMC Medicine. 15, 9 p., 207.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Erratum to: Project Sanitarium: playing tuberculosis to its end game (J Comput High Educ DOI 10.1007/s12528-017-9145-1)

Donald, I., Meyer, K. A., Brengman, J., Gillespie, S. H. & Bowness, R., Dec 2017, In: Journal of Computing in Higher Education. 29, 3, p. 618-619 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Genomic investigation unmasks evidence of transmission across mycobacterium abscessus cystic fibrosis patients

Alateah, S., Peters, C., Dhasmana, D., Pettigrew, K., Fallon, R., Seagar, A.-L., Sloan, D., Laurenson, I., Holden, M. & Gillespie, S., 15 Dec 2017, In: Thorax. 72, Suppl 3, p. A56-A56

Research output: Contribution to journal › Abstract › peer-review

High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial

Boeree, M. J., Heinrich, N., Aarnoutse, R., Diacon, A. H., Dawson, R., Rehal, S., Kibiki, G. S., Churchyard, G., Sanne, I., Ntinginya, N. E., Minja, L. T., Hunt, R. D., Charalambous, S., Hanekom, M., Semvua, H. H., Mpagama, S. G., Manyama, C., Mtafya, B., Reither, K. & Wallis, R. S. & 10 others, Venter, A., Narunsky, K., Mekota, A., Henne, S., Colbers, A., Plemper van Balen, G., Gillespie, S. H., Phillips, P. P. J., Hoelscher, M. & PanACEA Consortium, Jan 2017, In: Lancet Infectious Diseases. 17, 1, p. 39-49 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Improved power for TB phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods

Svensson, R. J., Gillespie, S. H. & Simonsson, U. S. H., 1 Aug 2017, In: Journal of Antimicrobial Chemotherapy. 72, 8, p. 2311-2319 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Label-free optical vibrational spectroscopy to detect the metabolic state of M. tuberculosis cells at the site of disease

Baron, V., Chen, M., Clark, S. O., Williams, A., Hammond, R. J. H., Dholakia, K. & Gillespie, S. H., 29 Aug 2017, In: Scientific Reports. 7, 9 p., 9844.

Research output: Contribution to journal › Article › peer-review

Open Access

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Mycobacterial load assay

Gillespie, S. H., Sabiiti, W. & Oravcova, K., 2017, Diagnostic Bacteriology: Methods and Protocols. Bishop-Lilly, K. A. (ed.). New York, NY: Humana Press/Springer, p. 89-105 17 p. (Methods in Molecular Biology; vol. 1616).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Open Access

File

Pharmacokinetics, tolerability, and bacteriological response of rifampin administered at 600, 900, and 1,200 milligrams daily in patients with pulmonary tuberculosis

Aarnoutse, R. E., Kibiki, G. S., Reither, K., Semvua, H. H., Haraka, F., Mtabho, C. M., Mpagama, S. G., van den Boogaard, J., Sumari-de Boer, I. M., Magis-Escurra, C., Wattenberg, M., Logger, J. G. M., te Brake, L. H. M., Hoelscher, M., Gillespie, S. H., Colbers, A., Phillips, P. P. J., Plemper van Balen, G., Boeree, M. J. & PanACEA Consortium, 1 Nov 2017, In: Antimicrobial Agents and Chemotherapy. 61, 11, e01054-17.

Research output: Contribution to journal › Article › peer-review

Project Sanitarium: playing tuberculosis to its end game

Donald, I., Meyer, K., Brengman, J., Gillespie, S. H. & Bowness, R., Dec 2017, In: Journal of Computing in Higher Education. 29, 3, p. 599-617 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis

Murphy, M. E., Phillips, P. P. J., Mendel, C. M., Bongard, E., Bateson, A. L. C., Hunt, R., Murthy, S., Singh, K. P., Brown, M., Crook, A. M., Nunn, A. J., Meredith, S. K., Lipman, M., McHugh, T. D., Gillespie, S. H. & REMoxTB Consortium, 27 Oct 2017, In: BMC Medicine. 15, 10 p., 192.

Research output: Contribution to journal › Article › peer-review

Open Access

File

The implications of model–informed drug discovery and development for tuberculosis

Muliaditan, M., Davies, G. R., Simonsson, U. S. H., Gillespie, S. H. & Pasqua, O. D., Mar 2017, In: Drug Discovery Today. 22, 3, p. 481-486 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2016

A new trial design to accelerate tuberculosis drug development: the Phase IIC Selection Trial with Extended Post-treatment follow-up (STEP)

Phillips, P. P. J., Dooley, K. E., Gillespie, S. H., Heinrich, N., Stout, J. E., Nahid, P., Diacon, A. H., Aarnoutse, R. E., Kibiki, G. S., Boeree, M. J. & Hoelscher, M., 23 Mar 2016, In: BMC Medicine. 14, p. 1-11 11 p., 51.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Defining dormancy in mycobacterial disease

Lipworth, S., Hammond, R. J. H., Baron, V. O., Hu, Y., Coates, A. & Gillespie, S. H., Jul 2016, In: Tuberculosis. 99, p. 131-142 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Erratum to: Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials: limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials

Phillips, P. P. J., Mendel, C. M., Burger, D. A., Crook, A. M., Nunn, A. J., Dawson, R., Diacon, A. H. & Gillespie, S. H., 23 Feb 2016, In: BMC Medicine. 14, 36.

Research output: Contribution to journal › Article

Open Access

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Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials

Phillips, P. P. J., Mendel, C. M., Burger, D. A., Crook, A., Nunn, A. J., Dawson, R., Diacon, A. H. & Gillespie, S. H., 4 Feb 2016, In: BMC Medicine. 14, 11 p., 19.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Optimising molecular diagnostic capacity for effective control of tuberculosis in high-burden settings

Sabiiti, W., Mtafya, B., Kuchaka, D., Azam, K., Viegas, S., Mdolo, A., Farmer, E., Khonga, M., Evangelopoulos, D., Honeyborne, I., Rachow, A., Heinrich, N., Ntinginya, N. E., Bhatt, N., Davies, G. R., Jani, I. V., McHugh, T. D., Kibiki, G., Hoelscher, M. & Gillespie, S. H. & 1 others, PANBIOME (Pan-African Biomarker Expansion Programme) consortium, 1 Aug 2016, In: International Journal of Tuberculosis and Lung Disease. 20, 8, p. 1004-1009

Research output: Contribution to journal › Article › peer-review

Open Access

File

Profiling persistent tubercule bacilli from patient sputa during therapy predicts early drug efficacy

Honeyborne, I., McHugh, T. D., Kuittinen, I., Cichonska, A., Evangelopoulos, D., Ronacher, K., van Helden, P. D., Gillespie, S. H., Fernandez-Reyes, D., Walzl, G., Rousu, J., Butcher, P. D. & Waddell, S. J., 7 Apr 2016, In: BMC Medicine. 14, 1, p. 1-13 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Therapy for Tuberculous Meningitis

Boeree, M. J., Gillespie, S. H., Hoelscher, M. & PanACEA core team, 2 Jun 2016, In: New England Journal of Medicine. 374, 22, p. 2187-8 2 p.

Research output: Contribution to journal › Letter

The role of moxifloxacin in tuberculosis therapy

Gillespie, S. H., Mar 2016, In: European Respiratory Review. 25, 139, p. 19-28 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

To the editor

Boeree, M. J., Gillespie, S. H. & Hoelscher, M., 2 Jun 2016, In: New England Journal of Medicine. 374, 22, p. 2187-2188 2 p.

Research output: Contribution to journal › Letter › peer-review

2015

A dose ranging trial to optimize the dose of Rifampin in the treatment of tuberculosis

Boeree, M. J., Diacon, A. H., Dawson, R., Narunsky, K., du Bois, J., Venter, A., Phillips, P. P. J., Gillespie, S. H., Mc Hugh, T. D., Hoelscher, M., Heinrich, N., Rehal, S., van Soolingen, D., van Ingen, J., Magis-Escurra, C., Burger, D., Plemper van Balen, G., Aarnoutse, R. E. & PanACEA Consortium, 1 May 2015, In: American Journal of Respiratory and Critical Care Medicine. 191, 9, p. 1058-1065

Research output: Contribution to journal › Article › peer-review

Open Access

File

A Step toward an Optimized Rifampin Dose Completed

Boeree, M. J., Diacon, A. H., Dawson, R., Narunsky, K., du Bois, J., Venter, A., Phillips, P. P. J., Gillespie, S. H., McHugh, T. D., Hoelscher, M., Heinrich, N., Rehal, S., van Soolingen, D., van Ingen, J., Magis-Escurra, C., Burger, D., Plemper van Balen, G. & Aarnoutse, R. E., 15 Aug 2015, In: American Journal of Respiratory and Critical Care Medicine. 192, 4, p. 525-6 2 p.

Research output: Contribution to journal › Article › peer-review

Early phase evaluation of SQ109 alone and in combination with rifampicin in pulmonary TB patients

Heinrich, N., Dawson, R., du Bois, J., Narunsky, K., Horwith, G., Phipps, A. J., Nacy, C. A., Aarnoutse, R. E., Boeree, M. J., Gillespie, S. H., Venter, A., Henne, S., Rachow, A., Phillips, P. P. J., Hoelscher, M., Diacon, A. H. & Pan African Consortium for the Evaluation of Antituberculosis Antibiotics (PanACEA), 27 Jan 2015, In: Journal of Antimicrobial Chemotherapy.

Research output: Contribution to journal › Article › peer-review

Effective anti-tuberculosis therapy correlates with plasma small RNA

Honeyborne, I., Lipman, M. C., Eckold, C., Evangelopoulos, D., Gillespie, S. H., Pym, A. & McHugh, T. D., 1 Jun 2015, In: European Respiratory Journal. 45, 6, p. 1741-1744

Research output: Contribution to journal › Article › peer-review

Genomic investigations unmask Mycoplasma amphoriforme, a new respiratory pathogen

Gillespie, S. H., Ling, C. L., Oravcova, K., Pinheiro, M., Wells, L., Bryant, J. M., McHugh, T. D., Bébéar, C., Webster, D., Harris, S. R., Seth-Smith, H. M. B. & Thomson, N. R., 1 Feb 2015, In: Clinical Infectious Diseases. 60, 3, p. 381-388 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

HspX knock-out in Mycobacterium tuberculosis leads to shorter antibiotic treatment and lower relapse rate in a mouse model - A potential novel therapeutic target

Hu, Y., Liu, A., Menendez, M. C., Garcia, M. J., Oravcova, K., Gillespie, S. H., Davies, G. R., Mitchison, D. A. & Coates, A. R. M., Jan 2015, In: Tuberculosis. 95, 1, p. 31-36 6 p.

Research output: Contribution to journal › Article › peer-review

Phenotypic resistance in mycobacteria: is it because I am old or fat that I resist you?

Hammond, R. J. H., Baron, V. O., Oravcova, K., Lipworth, S. & Gillespie, S. H., 9 Jul 2015, In: Journal of Antimicrobial Chemotherapy. Advance Access

Research output: Contribution to journal › Article › peer-review

Open Access

File

Project Sanitarium: gaming TB - A serious game for a serious problem

Donald, I., Meyer, K., Gillespie, S. H., Bowness, R. & Brengman, J., 16 Sept 2015, 7th International Conference on Games and Virtual Worlds for Serious Applications, VS-Games 2015. IEEE, 8 p. 7295782

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Open Access

File

Respiratory Mycoplasma Infections

Gillespie, S. H., Oravcova, K. & Monnier Hovell, Z., 2015, (Accepted/In press)

Research output: Non-textual form › Digital or Visual Products

Shorter moxifloxacin-based regimens for drug-sensitive tuberculosis

Gillespie, S. H., Mendel, C. M., Phillips, P. P. J. & REMoxTB Consortium, 5 Feb 2015, In: New England Journal of Medicine. 372, 6, p. 577-577 1 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

File

The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations

Bowness, R., Boeree, M. J., Aarnoutse, R., Dawson, R., Diacon, A., Mangu, C., Heinrich, N., Ntinginya, N. E., Kohlenberg, A., Mtafya, B., Phillips, P. P. J., Rachow, A., Plemper van Balen, G. & Gillespie, S. H., Feb 2015, In: Journal of Antimicrobial Chemotherapy. 70, 2, p. 448-455 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2014

Community-acquired pneumonia and tuberculosis: differential diagnosis and the use of fluoroquinolones

Grossman, R. F., Hsueh, P.-R., Gillespie, S. H. & Blasi, F., 1 Jan 2014, In: International Journal of Infectious Diseases. 18, 1, p. 14-21 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Editor of a series on Respiratory Infections for Henry Stewart Talks

Gillespie, S. H., 2014

Research output: Non-textual form › Digital or Visual Products

Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis

Gillespie, S. H., Crook, A. M., McHugh, T. D., Mendel, C. M., Meredith, S. K., Murray, S. R., Pappas, F., Phillips, P. P. J., Nunn, A. J. & for the REMoxTB Consortium, 23 Oct 2014, In: New England Journal of Medicine. 371, 17, p. 1577-1587 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects

Zumla, A. I., Gillespie, S. H., Hoelscher, M., Philips, P. P. J., Cole, S. T., Abubakar, I., McHugh, T. D., Schito, M., Maeurer, M. & Nunn, A. J., Apr 2014, In: Lancet Infectious Diseases. 14, 4, p. 327-40 14 p.

Research output: Contribution to journal › Article › peer-review

Tools for detection of Mycoplasma amphoriforme: a primary respiratory pathogen?

Ling, C. L., Oravcova, K., Beattie, T. F., Creer, D. D., Dilworth, P., Fulton, N. L., Hardie, A., Munro, M., Pond, M., Templeton, K., Webster, D., Workman, S., McHugh, T. D. & Gillespie, S. H., Apr 2014, In: Journal of Clinical Microbiology. 52, 4, p. 1177-1181 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Tuberculosis new treatments in evolution: Henry Stewart Talks

Gillespie, S. H., 2014

Research output: Non-textual form › Digital or Visual Products

2013

Assessment of the sensitivity and specificity of Xpert MTB/RIF assay as an early sputum biomarker of response to tuberculosis treatment

Friedrich, S. O., Rachow, A., Saathoff, E., Singh, K., Mangu, C. D., Dawson, R., Phillips, P., Venter, A., Bateson, A., Boehme, C. C., Heinrich, N., Hunt, R., Boeree, M. J., Zumla, A., McHugh, T. D., Gillespie, S. H., Diacon, A. & Hoelscher, M., 2013, In: The Lancet Respiratory Medicine. 1, 6, p. 462-470 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Chasing Koch's chimera

Klatser, P., Anthony, R., Barry, C., Drobniewski, F., Hoffner, S., Niemann, S. & Gillespie, S., 1 Jan 2013, In: The Lancet Infectious Diseases. 13, 4, p. 289-291 3 p.

Research output: Contribution to journal › Letter › peer-review

Clinical trials in tuberculosis chemotherapy: The challenges

Gillespie, S. H., 25 Apr 2013, Tuberculosis: Laboratory Diagnosis and Treatment Strategies. CABI Publishing, p. 197-205 9 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Direct comparison of Xpert MTB/RIF assay with liquid and solid mycobacterial culture for quantification of early bactericidal activity

Kayigire, X. A., Friedrich, S. O., Venter, A., Dawson, R., Gillespie, S. H., Boeree, M. J., Heinrich, N., Hoelscher, M. & Diacon, A. H., Apr 2013, In: Journal of Clinical Microbiology. 51, 6, p. 1894-1898 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Stephen Henry Gillespie

Research output

Search results