Research output per year
Research output per year
Personal profile
Research overview
In healthy individuals, the controlled release of calcium causes the heart to beat strongly. Calcium is released through specialised gates called ryanodine receptors (RyR2). In patients with heart failure and fatal arrhythmias the release of calcium becomes erratic leading to weakened contraction of heart muscle and cell death. Using a combination of low noise electrophysiological recordings in combination with molecular and biochemical methods my group investigates intracellular calcium dynamics and the molecular function of RyR2 and other ion channels that are present on intracellular organelles. The aim of our research is to try to understand what happens to channel function under pathophysiological conditions.
Profile Keywords
Cardiac Dysfunction; Intracellular Calcium Dynamics; Ion Channel; Metal Ion Homeostasis
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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6 Does mitsugumin 23 play a role in doxorubicin-induced cardiotoxicity?
Abraham, K., Dorward, A. M., Hurst, Q. & Pitt, S. J., 1 Apr 2023, In: Heart. 109, Suppl 2, p. A2-A2 1 p.Research output: Contribution to journal › Abstract › peer-review
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Editorial: Insulin resistance and cardiovascular disease
Stewart, A. J., Tuncay, E., Pitt, S. J. & Rainbow, R. D., 4 Aug 2023, In: Frontiers in Endocrinology. 14, 3 p., 1266173.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile6 Downloads (Pure) -
Magnesium deficiency and cardiometabolic disease
Fritzen, R., Davies, A., Veenhuizen, M., Campbell, M., Pitt, S. J., Ajjan, R. A. & Stewart, A. J., 17 May 2023, In: Nutrients. 15, 10, 19 p., 2355.Research output: Contribution to journal › Review article › peer-review
Open AccessFile11 Citations (Scopus)9 Downloads (Pure) -
The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart
Dorward, A. M., Stewart, A. J. & Pitt, S. J., 16 Jun 2023, In: Journal of General Physiology. 155, 7, 18 p., e202213206.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)25 Downloads (Pure) -
Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes
Sobczak, A. I. S., Katundu, K. G. H., Phoenix, F. A., Khazaipoul, S., Yu, R., Lampiao, F., Stefanowicz, F., Blindauer, C. A., Pitt, S. J., Smith, T. K., Ajjan, R. A. & Stewart, A. J., 21 Mar 2021, In: Chemical Science. 12, 11, p. 4079-4093 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)6 Downloads (Pure)
Datasets
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Data Underpinning - Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets
Kapsalis, C. (Creator), Wang, B. (Creator), El Mkami, H. (Creator), Pitt, S. J. (Creator), Schnell, J. (Creator), Smith, T. K. (Creator), Lippiat, J. (Creator), Bode, B. E. (Creator) & Pliotas, C. (Creator), University of St Andrews, 2019
DOI: 10.17630/fa8518b0-13ba-4b11-bad4-e5c6b000738d
Dataset
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Monitoring contractility in cardiac tissue with cellular resolution using biointegrated microlasers (dataset)
Schubert, M. (Creator), Woolfson, L. (Creator), Barnard, I. R. M. (Creator), Dorward, A. (Creator), Casement, B. (Creator), Morton, A. (Creator), Robertson, G. B. (Creator), Appleton, P. L. (Creator), Miles, G. B. (Creator), Tucker, C. S. (Creator), Pitt, S. J. (Creator) & Gather, M. C. (Creator), University of St Andrews, 15 Jun 2020
DOI: 10.17630/97927f1f-a111-46d0-8d41-038771733b73
Dataset
File
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Dr S Pitt - Studentship: Mitsugumin 23 in cardio(vascular) disorders – genomic and functional approaches
Pitt, S. J. (PI) & Paracchini, S. (CoI)
1/09/23 → 31/08/26
Project: Standard
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ISSF Round 7 - Samantha Pitt: ISSF Round 7 - Samantha Pitt
Pitt, S. J. (PI)
1/02/22 → 31/07/22
Project: Standard
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High-resolution structure: High-resolution structure, function and anti-viral inhibition of the SARS-CoV2 E protien ion channel
Pitt, S. J. (PI)
8/02/21 → 7/08/22
Project: Standard
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Enabling Shaped Pulse Capability: Enabling Shaped Pulse Capability for Superior Biological Structural Determination Using EPR Spectroscopy.
Lovett, J. E. (PI), Bode, B. E. (CoI), Penedo, C. (CoI), Pitt, S. J. (CoI), Schwarz-Linek, U. (CoI), Smith, G. M. (CoI), Watson, A. J. B. (CoI) & White, M. (CoI)
1/10/20 → 30/09/21
Project: Standard
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Role of Mitsugumin23: Determining the Role of the newly identified calcium release channel Mitsugumin23 in hypoxiainduced apoptosis
Pitt, S. J. (PI)
3/06/19 → 26/07/19
Project: Studentship
Activities
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Keynote Talk: Zinc-Net Meeting 2019
Pitt, S. J. (Participant)
18 Jan 2019Activity: Participating in or organising an event types › Participation in or organising a public festival/exhibition/event
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Invited Talk - Cardiac dysfunction and the role of zinc in sarcoplasmic reticulum remodelling
Pitt, S. J. (Speaker)
3 Jun 2018 → 8 Jun 2018Activity: Talk or presentation types › Invited talk
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British Heart Foundation Scotland’s Parliamentary Reception
Pitt, S. J. (Participant)
31 Jan 2018Activity: Participating in or organising an event types › Participation in or organising a public festival/exhibition/event
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British Heart Foundation Scotland’s Stakeholder Dinner
Pitt, S. J. (Participant)
2018 → …Activity: Participating in or organising an event types › Participation in or organising a public festival/exhibition/event
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Dysregulated zinc may lead to ‘leaky’ calcium channels in heart failure - International Society for Zinc Biology Conference 2017, Pyla, Cyprus
Pitt, S. J. (Speaker)
19 Jun 2017Activity: Talk or presentation types › Invited talk
Prizes
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Royal Society of Edinburgh Biomedical Fellowship
Pitt, S. J. (Recipient), 1 Oct 2013
Prize: Prize (including medals and awards)