Research output per year
Research output per year
- 1 - 50 out of 54 results
Search results
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2025
Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin
Ishimoto, N., Wong, J. L. C., He, S., Shirran, S., Wright-Paramio, O., Seddon, C., Singh, N., Balsalobre, C., Sonani, R. R., Clements, A., Egelman, E. H., Frankel, G. & Beis, K., 22 Apr 2025, In: Proceedings of the National Academy of Sciences. 122, 16, p. 1-8 8 p., e2427228122.Research output: Contribution to journal › Article › peer-review
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Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery
Ahmed, H., Fernandes, M. F., Abbas, K., Synowsky, S. A., Shirran, S. L., Ajjan, R. A. & Stewart, A. J., May 2025, In: Diabetes, Obesity and Metabolism. 27, 5, p. 2647-2657 11 p.Research output: Contribution to journal › Article › peer-review
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2024
Characterising the HLA-I Immunopeptidome of plasma-derived extracellular vesicles in patients with melanoma
Boyne, C. M., Coote, A., Synowsky, S. A., Naden, A. B., Shirran, S. L. & Powis, S. J., Mar 2024, In: Journal of Extracellular Biology. 3, 3, 12 p., e146.Research output: Contribution to journal › Article › peer-review
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Reversible conjugation of a CBASS nucleotide cyclase regulates bacterial immune response to phage infection
Kruger, L., Gaskell-Mew, L., Graham, S., Shirran, S. L., Hertel, R. & White, M., 8 Apr 2024, In: Nature Microbiology. 9, p. 1579-1592 33 p.Research output: Contribution to journal › Article › peer-review
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2023
AAV9-mediated SMN gene therapy rescues cardiac desmin but not Lamin A/C and elastin dysregulation in Smn2B/- spinal muscular atrophy mice
Brown, S. J., Šoltić, D., Synowsky, S. A., Shirran, S. L., Chilcott, E., Shorrock, H. K., Gillingwater, T. H., Yáñez-Muñoz, R. J., Schneider, B., Bowerman, M. & Fuller, H. R., 15 Oct 2023, In: Human Molecular Genetics. 32, 20, p. 2950-2965 16 p.Research output: Contribution to journal › Article › peer-review
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Antiviral type III CRISPR signalling via conjugation of ATP and SAM
Chi, H., Hoikkala, V. P., Gruschow, S., Graham, S., Shirran, S. L. & White, M., 26 Oct 2023, In: Nature. 622, 7984, p. 826-833 22 p.Research output: Contribution to journal › Article › peer-review
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Assessing the impact of interfering organic matter on soil metaproteomic workflow
Waibel, M., McDonnell, K., Tuohy, M., Shirran, S., Synowsky, S., Thornton, B., Paterson, E., Brennan, F. & Abram, F., 22 Jun 2023, In: European Journal of Soil Science. 74, 3, 14 p., e13392.Research output: Contribution to journal › Article › peer-review
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Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis
Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., Smith, B. O., Kalinina, O. V., Müller, R. & Koehnke, J., 1 Apr 2023, In: Nature Chemistry. 15, 4, p. 560-568 9 p.Research output: Contribution to journal › Article › peer-review
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2022
Carbapenem-only combination therapy against multi-drug resistant Pseudomonas aeruginosa: assessment of in vitro and in vivo efficacy and mode of action
Mackay, B., Parcell, B. J., Shirran, S. L. & Coote, P. J., 25 Oct 2022, In: Antibiotics. 11, 11, 19 p., 1467.Research output: Contribution to journal › Article › peer-review
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Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS
Guo, N., Minas, G., Synowsky, S. A., Dunne, M. R., Ahmed, H., McShane, R., Bhardwaj, A., Donlon, N. E., Lorton, C., O'Sullivan, J., Reynolds, J. V., Caie, P. D., Shirran, S. L., Lynch, A., Stewart, A. J. & Arya, S., 30 Aug 2022, In: Journal of Proteomics. 266, 11 p., 104684.Research output: Contribution to journal › Article › peer-review
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Structure, dynamics, and molecular inhibition of the Staphylococcus aureus m1A22-tRNA methyltransferase TrmK
Sweeney, P., Galliford, A., Kumar, A., Raju, D., Krishna, N. B., Sutherland, E., Leo, C. J., Fisher, G., Lalitha, R., Muthuraj, L., Sigamani, G., Oehler, V., Synowsky, S. A., Shirran, S. L., Gloster, T., Melo Czekster, C., Kumar, P. & da Silva, R. G., May 2022, In: Journal of Biological Chemistry. 298, 6, 15 p., 102040.Research output: Contribution to journal › Article › peer-review
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The proteome signatures of fibroblasts from patients with severe, intermediate and mild spinal muscular atrophy show limited overlap
Brown, S. J., Kline, R. A., Synowsky, S. A., Shirran, S. L., Holt, I., Sillence, K. A., Claus, P., Wirth, B., Wishart, T. M. & Fuller, H. R., 23 Aug 2022, In: Cells. 11, 17, 25 p., 2624.Research output: Contribution to journal › Article › peer-review
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Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles
Kumar, P., Boyne, C., Brown, S. E., Qureshi, A., Thorpe, P. J., Synowsky, S. A., Shirran, S. L. & Powis, S. J., 1 Jun 2022, In: Immunology. 166, 2, p. 249-264 15 p., 13471.Research output: Contribution to journal › Article › peer-review
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2021
Direct synthesis of polyureas from the dehydrogenative coupling of diamines and methanol
Kumar, A., Armstrong, D., Peters, G., Nagala, M. & Shirran, S. L., 25 Jun 2021, In: Chemical Communications. 57, 50, p. 6153-6156 4 p.Research output: Contribution to journal › Article › peer-review
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Engineering of a peptide α-N-methyltransferase to methylate non-proteinogenic amino acids
Song, H., Burton, A. J., Shirran, S. L., Fahrig-Kamarauskaitė, J., Kaspar, H., Muir, T. W., Künzler, M. & Naismith, J. H., 15 Apr 2021, (E-pub ahead of print) In: Angewandte Chemie International Edition. Early View, 6 p.Research output: Contribution to journal › Article › peer-review
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Investigation of the blood proteome in response to spinal cord injury in rodent models
Hulme, C. H., Fuller, H. R., Riddell, J., Shirran, S. L., Botting, C. H., Osman, A. & Wright, K. T., 2 Oct 2021, In: Spinal cord. First Online, 6 p.Research output: Contribution to journal › Article › peer-review
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Resource recovery from the anaerobic digestion of food waste is underpinned by cross-kingdom microbial activities
Nzeteu, C., Joyce, A., Thorn, C., McDonnell, K., Shirran, S., O'Flaherty, V. & Abram, F., Dec 2021, In: Bioresource Technology Reports. 16, 9 p., 100847.Research output: Contribution to journal › Article › peer-review
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2020
Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development
Beiersdorf, J., Hevesi, Z., Calvigioni, D., Pyszkowski, J., Romanov, R., Szodorai, E., Lubec, G., Shirran, S., Botting, C. H., Kasper, S., Guy, G. W., Gray, R., Di Marzo, V., Harkany, T. & Keimpema, E., 3 Dec 2020, In: JCI Insight. 5, 23, 20 p., e135418.Research output: Contribution to journal › Article › peer-review
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An interaction of heart disease-associated proteins POPDC1/2 with XIRP1 in transverse tubules and intercalated discs
Holt, I., Fuller, H. R., Schindler, R. F. R., Shirran, S. L., Brand, T. & Morris, G. E., 1 Dec 2020, In: BMC Molecular and Cell Biology. 21, 13 p., 88.Research output: Contribution to journal › Article › peer-review
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Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: implications for idiopathic Parkinson’s disease
Gómez-Gálvez, Y., Fuller, H. R., Synowsky, S., Shirran, S. L. & Gates, M. A., 9 Apr 2020, (E-pub ahead of print) In: Journal of Neuroscience Research. Early view, 16 p.Research output: Contribution to journal › Article › peer-review
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Substrate plasticity of a fungal peptide α-N-methyltransferase
Song, H., Fahrig-Kamarauskaite, J., Matabaro, E., Kaspar, H., Shirran, S. L., Zach, C., Pace, A., Stefanov, B.-A., Naismith, J. H. & Kunzler, M., 17 Jul 2020, In: ACS Chemical Biology. 15, 7, p. 1901-1912 12 p.Research output: Contribution to journal › Article › peer-review
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2019
Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy"
Šoltić, D., Shorrock, H. K., Allardyce, H., Wilson, E. L., Holt, I., Synowsky, S. A., Shirran, S. L., Parson, S., Gillingwater, T. & Fuller, H., 9 Aug 2019, (E-pub ahead of print) In: Human Molecular Genetics. Advance ArticleResearch output: Contribution to journal › Article › peer-review
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Life-long epigenetic programming of cortical architecture by maternal ‘Western’ diet during pregnancy
Cinquina, V., Calvigioni, D., Farlik, M., Halbritter, F., Fife-Gernedl, V., Shirran, S. L., Fuszard, M. A., Botting, C. H., Poullet, P., Piscitelli, F., Máte, Z., Szabo, G., Yanagawa, Y., Kasper, S., Di Marzo, V., Mackie, K., McBain, C., Bock, C., Keimpema, E. & Harkany, T., 18 Nov 2019, (E-pub ahead of print) In: Molecular Psychiatry. 15 p.Research output: Contribution to journal › Article › peer-review
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Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle
Holt, I., Fuller, H. R., Lam, L. T., Sewry, C. A., Shirran, S. L., Zhang, Q., Shanahan, C. M. & Morris, G. E., 2 Oct 2019, In: Scientific Reports. 9, 12 p., 14202.Research output: Contribution to journal › Article › peer-review
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Quantitative proteomic changes in LPS-activated monocyte-derived dendritic cells: a SWATH-MS study
Arya, S., Wiatrek-Moumoulidis, D., Synowsky, S. A., Shirran, S. L., Botting, C. H., Powis, S. J. & Stewart, A. J., 13 Mar 2019, In: Scientific Reports. 9, 11 p., 4343.Research output: Contribution to journal › Article › peer-review
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2018
A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds
Song, H., Van Der Velden, N. S., Shirran, S. L., Bleiziffer, P., Zach, C., Sieber, R., Imani, A. S., Krausbeck, F., Aebi, M., Freeman, M. F., Riniker, S., Künzler, M. & Naismith, J. H., 24 Aug 2018, In: Science Advances. 4, 8, 13 p., eaat2720.Research output: Contribution to journal › Article › peer-review
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Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs)
Hulme, C. H., Wilson, E., Fuller, H. R., Roberts, S., Richardson, J. B., Gallacher, P., Peffers, M. J., Shirran, S. L., Botting, C. H. & Wright, K. T., Dec 2018, In: International journal of experimental pathology. 99, 6, p. A2-A2 1 p.Research output: Contribution to journal › Abstract › peer-review
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Linking microbial community structure and function during the acidified anaerobic digestion of grass
Joyce, A., Ijaz, U. Z., Nzeteu, C., Vaughan, A., Shirran, S. L., Botting, C. H., Quince, C., O’Flaherty, V. & Abram, F., 21 Mar 2018, In: Frontiers in Microbiology. 9, 13 p.Research output: Contribution to journal › Article › peer-review
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Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology
Thompson, L. W., Morrison, K. D., Shirran, S. L., Groen, E. J. N., Gillingwater, T. H., Botting, C. H. & Sleeman, J. E., 17 Apr 2018, In: Journal of Cell Science. 131, 8, 18 p., jcs211482.Research output: Contribution to journal › Article › peer-review
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Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration
Arya, S., Emri, E., Synowsky, S. A., Shirran, S. L., Barzegar-Befroei, N., Peto, T., Botting, C. H., Lengyel, I. & Stewart, A. J., Jul 2018, In: Experimental Eye Research. 172, p. 21-29 9 p.Research output: Contribution to journal › Article › peer-review
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Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation
Hulme, C. H., Wilson, E. L., Fuller, H. R., Roberts, S., Richardson, J. B., Gallacher, P., Peffers, M. J., Shirran, S. L., Botting, C. H. & Wright, K. T., 2 May 2018, In: Arthritis Research & Therapy. 20, 17 p., 87.Research output: Contribution to journal › Article › peer-review
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2017
Contaminants in commercial preparations of ‘purified’ small leucine-rich proteoglycans may distort mechanistic studies
Brown, S. J., Fuller, H. R., Jones, P., Caterson, B., Shirran, S. L., Botting, C. H. & Roberts, S., Feb 2017, In: Bioscience Reports. 37, 1, 14 p.Research output: Contribution to journal › Article › peer-review
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hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases
Ashton, N. W., Paquet, N., Shirran, S. L., Bolderson, E., Kariawasam, R., Touma, C., Fallahbaghery, A., Gamsjaeger, R., Cubeddu, L., Botting, C., Pollock, P. M., O’Byrne, K. J. & Richard, D. J., Jun 2017, In: DNA Repair. 54, p. 30-39 10 p.Research output: Contribution to journal › Article › peer-review
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The major histocompatibility complex class I immunopeptidome of extracellular vesicles
Synowsky, S. A., Shirran, S. L., Cooke, F. G. M., Antoniou, A. N., Botting, C. H. & Powis, S. J., 13 Oct 2017, In: Journal of Biological Chemistry. 292, p. 17084-17092Research output: Contribution to journal › Article › peer-review
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2016
Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase
Shi, X., Botting, C. H., Li, P., Niglas, M., Brennan, B., Shirran, S. L., Szemiel, A. M. & Elliott, R. M., 2 Aug 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 31, p. 8825-8830 6 p.Research output: Contribution to journal › Article › peer-review
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On the interaction between human IQGAP1 and actin
Magill, D., Hamilton, E., Shirran, S. L., Botting, C. H. & Timson, D., 2016, In: Protein & Peptide Letters. 23, 4Research output: Contribution to journal › Article › peer-review
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Rapid evolution and gene expression: a rapidly-evolving Mendelian trait that silences field crickets has widespread effects on mRNA and protein expression
Pascoal, S. C. M., Liu, X., Ly, T., Fang, Y., Rockliffe, N., Paterson, S., Shirran, S. L., Botting, C. H. & Bailey, N. W., Jun 2016, In: Journal of Evolutionary Biology. 29, 6, p. 1234-1246 13 p.Research output: Contribution to journal › Article › peer-review
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Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development
Fuller, H., Mandefro, B., Shirran, S. L., Gross, A., Kaus, A., Botting, C. H., Morris, G. & Sareen, D., 11 Jan 2016, In: Frontiers in Cellular Neuroscience. 9, 506.Research output: Contribution to journal › Article › peer-review
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Synthesis of next generation maleimide radical labels
Hajjaj, B., Shah, A., Bell, S., Shirran, S. L., Botting, C. H., Slawin, A. M. Z., Hulme, A. & Lovett, J. E., Oct 2016, In: Synlett. p. 2357-2361 5 p., 27.Research output: Contribution to journal › Article › peer-review
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2015
An internal thioester in a pathogen surface protein mediates covalent host binding
Walden, M., Edwards, J. M., Dziewulska, A. M., Bergmann, R., Saalbach, G., Kan, S.-Y., Miller, O. K., Weckener, M., Jackson, R. J., Shirran, S. L., Botting, C. H., Florence, G. J., Rohde, M., Banfield, M. J. & Schwarz-Linek, U., 2 Jun 2015, In: eLife. 4, 24 p., e06638.Research output: Contribution to journal › Article › peer-review
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A secretagogin locus of the mammalian hypothalamus controls stress hormone release
Romanov, R. A., Alpár, A., Zhang, M.-D., Zeisel, A., Calas, A., Landry, M., Fuszard, M. A., Shirran, S. L., Schnell, R., Dobolyi, Á., Oláh, M., Spence, L., Mulder, J., Martens, H., Palkovits, M., Uhlen, M., Sitte, H. H., Botting, C. H., Wagner, L. & Linnarsson, S. & 2 others, , 2 Jan 2015, In: EMBO Journal. 34, 1, p. 36-54Research output: Contribution to journal › Article › peer-review
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Stathmin is enriched in the developing corticospinal tract
Fuller, H., Slade, R., Jovanov-Milošević, N., Babić, M., Sedmak, G., Šimić, G., Fuszard, M. A., Shirran, S. L., Botting, C. H. & Gates, M., 2015, In: Molecular and Cellular Neuroscience. In pressResearch output: Contribution to journal › Article › peer-review
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Structural analysis of leader peptide binding enables leader-free cyanobactin processing
Koehnke, J. A. J. G., Mann, G., Bent, A. F., Ludewig, H., Shirran, S. L., Botting, C. H., Lebl, T., Houssen, W., Jaspers, M. & Naismith, J., Aug 2015, In: Nature Chemical Biology. 11, 8, p. 558-563 8 p.Research output: Contribution to journal › Article › peer-review
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2014
Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis
Kasioulis, I., Syred, H. M., Tate, P., Finch, A., Shaw, J., Seawright, A., Fuszard, M. A., Botting, C. H., Shirran, S., Adams, I. R., Jackson, I. J., van Heyningen, V. & Yeyati, P. L., 15 Apr 2014, In: Molecular Biology of the Cell. 25, 8, p. 1216-1233 18 p.Research output: Contribution to journal › Article › peer-review
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Miswiring the brain: delta(9)-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway
Tortoriello, G., Morris, C. V., Alpar, A., Fuzik, J., Shirran, S. L., Calvigioni, D., Keimpema, E., Botting, C. H., Reinecke, K., Herdegen, T., Courtney, M., Hurd, Y. L. & Harkany, T., 1 Apr 2014, In: EMBO Journal. 33, 7, p. 668-685 18 p.Research output: Contribution to journal › Article › peer-review
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2013
An enzymatic route to selenazolines
Koehnke, J., Morawitz, F., Bent, A. F., Houssen, W. E., Shirran, S. L., Fuszard, M. A., Smellie, I. A., Botting, C. H., Smith, M. C. M., Jaspars, M. & Naismith, J. H., 18 Mar 2013, In: ChemBioChem. 14, 5, p. 564-567 4 p.Research output: Contribution to journal › Article › peer-review
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The cyanobactin heterocyclase enzyme: A processive adenylase that operates with a defined order of reaction
Koehnke, J. A. J. G., Bent, A. F., Zollman, D., Smith, K., Houssen, W. E., Zhu, X., Mann, G., Lebl, T., Scharff, R., Shirran, S. L., Botting, C. H., Jaspers, M., Schwarz-Linek, U. & Naismith, J., Dec 2013, In: Angewandte Chemie International Edition. 52, 52, p. 13991-13996 7 p.Research output: Contribution to journal › Article › peer-review
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2012
The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain
Koehnke, J. A. J. G., Bent, A. F., Houssen, W. E., Zollman, D., Morawitz, F., Shirran, S. L., Vendome, J., Nneoyiegbe, A. F., Trembleau, L., Botting, C. H., Smith, M. C. M., Jaspars, M. & Naismith, J., Aug 2012, In: Nature Structural and Molecular Biology. 19, 8, p. 767-772 6 p.Research output: Contribution to journal › Article › peer-review
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2011
Design and Synthesis of confromationally constricted cyclophillin inhibitirs showng a cyclosporin A phenotype in C elegans.
Shirran, S. L., Barran, P., Dunsmore, C., Malone, K., Bailey, K., Wear, M., Florance, H., Page, A., Walkinshaw, M. & Turner, N., 1 Feb 2011, In: ChemBioChem. 12, 5, p. 802 8 p.Research output: Contribution to journal › Article › peer-review
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Global network analysis of drug tolerance, mode of action and virulence in methicillin-resistant S. aureus
Overton, I. M., Graham, S., Gould, K. A., Hinds, J., Botting, C. H., Shirran, S., Barton, G. J. & Coote, P. J., 12 May 2011, In: BMC Systems Biology. 5, 16 p., 68.Research output: Contribution to journal › Article › peer-review
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