Personal profile
Research overview
I manage the BSRC mass spectrometry core facility, which supports the research of many of the researchers within the Biomedical Sciences Research Complex, the University of St Andrews, and many other Universities in the UK. I am the first point of contact for collaborations, and will advise on experiment design and assist with interpretation of results.
The facility is mainly Proteomics based, specialising in 2 main areas:
Protein Identification - From simple gel band ID to identification of all proteins in a complex pullodwn mixture. Confirmation of post-translational modifications, spin labelling, chemical crosslinks, point mutations, truncations, all aspects of protein identification are supported. Measurement of intact protein mass is also undertaken, including membrane proteins.
Protein Quantitation - Relative protein quantitation by both iTRAQ and SWATH. Global protein quantitation upon exposure to stress.
Profile Keywords
Mass Spectrometry
Proteomics
Protein Identification
Protein Interactions
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger -
SDG 3 Good Health and Well-being -
SDG 7 Affordable and Clean Energy
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Collaborations and top research areas from the last five years
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Androgen receptor localisation and protein interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer
Bleach, R., Bozkurt, E., Xin, J., Sheehan, K. M., Shirran, S., Agbana, S., Ola, M., Young, L., Spoelstra, N. S., Richer, J. K., Vargas, A. C., Goldstein, L. D., Milloli, H. H., Chaffer, C. L., O'Reilly, M. W., Prehn, J. H. & McIlroy, M., 6 May 2026, In: npj Breast Cancer. 12, p. 1-17 17 p., 65.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Characterising PMP22 proximal partners in a Schwann cell model of Charcot-Marie-Tooth disease type1A
Holt, I., Emery, N., Gates, M. A., Brown, S. J., Shirran, S. & Fuller, H. R., 5 Nov 2025, In: Biology. 14, 11, p. 1-32 32 p., 1552.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin
Ishimoto, N., Wong, J. L. C., He, S., Shirran, S., Wright-Paramio, O., Seddon, C., Singh, N., Balsalobre, C., Sonani, R. R., Clements, A., Egelman, E. H., Frankel, G. & Beis, K., 22 Apr 2025, In: Proceedings of the National Academy of Sciences. 122, 16, p. 1-8 8 p., e2427228122.Research output: Contribution to journal › Article › peer-review
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Group A streptococcal SpeB modifies IgA through targeting regions other than the hinge
Vassen, V., Tanaka, E., Moll, K., Spoerry, C., Synowsky, S., Shirran, S. L., Schwarz-Linek, U., Loh, E., Svensson, M. & Norrby-Teglund, A., 6 May 2025, In: Microbiology Spectrum. 13, 5, e02450-24.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery
Ahmed, H., Fernandes, M. F., Abbas, K., Synowsky, S. A., Shirran, S. L., Ajjan, R. A. & Stewart, A. J., May 2025, In: Diabetes, Obesity and Metabolism. 27, 5, p. 2647-2657 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Ascomycota, Proteobacteria and Firmicutes drive resource recovery from the anaerobic digestion of food waste - Proteomics dataset
Nzeteu, C. (Contributor), Joyce, A. (Contributor), Thorn, C. (Contributor), McDonnell, K. (Contributor), Shirran, S. L. (Creator), O'Flaherty, V. (Contributor) & Abram, F. (Creator), University of St Andrews, 17 Jun 2021
DOI: 10.17630/e2603185-dc54-4034-9c73-bb20749caf60
Dataset
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Linking microbial community structure and function during the acidified anaerobic digestion of grass (16SrRNA sequence data)
Joyce, A. (Creator), Ijaz, U. Z. (Creator), Nzeteu, C. (Creator), Vaughan, A. (Creator), Shirran, S. L. (Creator), Botting, C. H. (Creator), Quince, C. (Creator), O’Flaherty, V. (Creator) & Abram, F. (Creator), National Center for Biotechnology Information, 5 Oct 2017
https://www.ncbi.nlm.nih.gov/Traces/study/?acc=SRP119456
Dataset
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Linking microbial community structure and function during the acidified anaerobic digestion of grass (Metaproteomic data)
Joyce, A. (Creator), Ijaz, U. Z. (Creator), Nzeteu, C. (Creator), Vaughan, A. (Creator), Shirran, S. L. (Creator), Botting, C. H. (Creator), Quince, C. (Creator), O’Flaherty, V. (Creator) & Abram, F. (Creator), Proteome Exchange, 7 Dec 2017
http://dx.doi.org/10.6019/PXD007956
Dataset
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Investigation of the blood proteome in response to spinal cord injury in rodent models (dataset)
Shirran, S. L. (Creator), ProteomeXchange Consortium via the PRIDE, 2021
http://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD021137
Dataset
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Antiviral Type III Crispr signalling via conjugation of STP and AdoMet
Shirran, S. (Creator) & Chi, H. (Creator), Figshare, 2023
DOI: 10.6084/m9.figshare.c.6646859.v1, https://doi.org/10.17630/sta/799
Dataset
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Research Technical Professionals: Recognising Leadership & Expertise (RELAX) in technical specialists
Homer, N. (PI), Murphy, L. (CoI), Shirran, S. (CoI), Whitfield, P. (CoI), Wilson, C. (CoI) & Cook, S. (CoI)
1/05/25 → 30/06/26
Project: Standard
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Native Mass Spectrometry, the first steps
Shirran, S. (PI) & Synowsky, S. (CoI)
British Mass Spectrometry Society
1/08/24 → 31/07/25
Project: Standard
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Slow release of antibiofilm peptides: Slow release of antibiofilm peptides to halt bone infections
Melo Czekster, C. (PI) & Shirran, S. (CoI)
1/10/23 → 31/03/25
Project: Standard
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New Liquidstate 400MHz NMR Spectrometer: A New Liquid-state 400MHz NMR Spectrometer for Molecular Characterisation
Shirran, S. (PI)
3/01/23 → 2/07/24
Project: Standard
Activities
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BBSRC 25TRT grant panel member
Shirran, S. (Advisor)
21 May 2026 → 22 May 2026Activity: Consultancy types › Consultancy and expert advice
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Isolated Biomolecules and Biomolecular Interactions 2026
Shirran, S. (Organiser)
20 Apr 2026 → 24 Apr 2026Activity: Participating in or organising an event types › Participation in or organising a conference
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Biochemical Journal (Journal)
Shirran, S. (Reviewer)
14 Apr 2026Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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Scottish Enterprise SPAC Research & Development workshop
Johnstone, J. (Organiser), Bruce, G. (Participant), Melo Czekster, C. (Participant), Ferreira Fernandes, M. (Participant), Hammond, R. (Participant), Ross, K. (Participant), Shirran, S. (Participant) & Zysman-Colman, E. (Participant)
14 Jan 2026Activity: Participating in or organising an event types › Participation in or organising a workshop, seminar, course
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Albumin, Bacteriodes, Cancer..to Zinc. A proteomics alphabet adventure
Shirran, S. L. (Speaker)
15 Nov 2024Activity: Talk or presentation types › Invited talk