Research output per year
Research output per year
Personal profile
Research overview
I am a Research Fellow working with Professor David Harrison. My current research interests are in establishing primary tumouroids from both renal and colorectal cancers using fresh tissue obtained from patients undergoing surgery. Methodolgy includes the use spinner flasks and / or microfluidic devices to establish 3D cultures (tumouroids) which, after treatment with either conventional or protide-modified drugs, can be collected and analysed by conventional techniques including immunofluorescence (IF).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A phosphoramidate modification of FUDR, NUC-3373, causes DNA damage and DAMPs release from colorectal cancer cells, potentiating lymphocyte-induced cell death
Read, O., Bre, J., Zhang, Y., Mullen, P., Elshani, M. & Harrison, D., 16 Sept 2025, In: PLoS One. 20, 9, p. 1-19 19 p., e0331567.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Kidney tumoroid characterisation by spatial mass spectrometry with same-section multiplex immunofluorescence uncovers tumour microenvironment lipid signatures associated with aggressive tumour phenotypes
Abdullah, H., Zickuhr, G. M., Um, I. H., Laird, A., Mullen, P., Harrison, D. J. & Dickson, A. L., 16 Sept 2025, In: npj Imaging. 3, p. 1-11 11 p., 43.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Defining the mode of action of cisplatin combined with NUC-1031, a phosphoramidate modification of gemcitabine
Patel, D., Dickson, A., Zickuhr, G. M., Um, I. H., Read, O. J., Melo Czekster, C., Mullen, P., Harrison, D. J. & Bre, J. L., 1 Dec 2024, In: Translational Oncology. 50, 11 p., 102114.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The novel anti-cancer fluoropyrimidine NUC-3373 is a potent inhibitor of thymidylate synthase and an effective DNA-damaging agent
Bré, J. L., Dickson, A., Read, O. J., Zhang, Y., McKissock, F. G., Mullen, P., Tang, P., Zickuhr, G. M., Melo Czekster, C. & Harrison, D. J., 31 Mar 2023, In: Cancer Chemotherapy and Pharmacology. 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Collateral-resistance to estrogen and HER-activated growth is associated with modified AKT, ERα and cell-cycle signaling in a breast cancer model
Moore, K. M., Cerqueira, V., MacLeod, K. G., Mullen, P., Hayward, R. L., Green, S., Harrison, D. J., Cameron, D. A. & Langdon, S. P., 28 Feb 2022, (E-pub ahead of print) In: Exploration of Targeted Anti-tumor Therapy. 3, p. 97-116 20 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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A phosphoramidate modification of FUDR, NUC-3373, causes DNA damage and DAMPs release from colorectal cancer cells, potentiating lymphocyte-induced cell death (dataset)
Read, O. (Creator), Bre, J. (Creator), Zhang, Y. (Creator), Mullen, P. (Creator), Elshani, M. (Creator) & Harrison, D. (Creator), GitHub, 2025
https://github.com/0R3ady/NUC3373_Immune_PONE
Dataset
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Clear Cell Renal Cell Carcinoma Patient-Derived Tumoroids characterisation by Spatial Mass Spectrometry, Histology and Multiplex Immunofluorescence
Zickuhr, G. M. (Creator), Abdullah, H. (Creator), Um, I. (Creator), Laird, A. (Creator), Mullen, P. (Creator), Harrison, D. (Creator) & Dickson, A. (Creator), EMBL-EBI, 2025
DOI: 10.6019/S-BIAD1661
Dataset
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Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction (dataset)
Wilkie, R. P. (Creator), Neal, A. (Creator), Johnston, C. A. (Creator), Voûte, N. (Creator), Lancefield, C. S. (Creator), Stell, M. (Creator), Medda, F. (Creator), Makiyi, E. F. (Creator), Turner, E. (Creator), Ojo, O. S. (Creator), Slawin, A. M. Z. (Creator), Lebl, T. (Creator), Mullen, P. (Creator), Harrison, D. J. (Creator), Ireland, C. M. (Creator) & Westwood, N. J. (Creator), Cambridge Crystallographic Data Centre, 2016
https://dx.doi.org/10.5517/ccdc.csd.cc1lwnlq and 3 more links, https://dx.doi.org/10.5517/ccdc.csd.cc1lm4bp, https://dx.doi.org/10.5517/ccdc.csd.cc1lm4cq, https://dx.doi.org/10.5517/ccdc.csd.cc1lm4dr (show fewer)
Dataset
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Clear Cell Renal Cell Carcinoma Patient-Derived Tumoroids characterisation by Spatial Mass Spectrometry, Histology and Multiplex Immunofluorescence (dataset)
Ross, K. (Creator), Zickuhr, G. M. (Creator), Abdullah, H. (Creator), Um, I. H. (Creator), Mullen, P. (Creator), Harrison, D. J. (Creator) & Dickson, A. (Creator), EMBL-EBI, 22 Feb 2025
DOI: 10.6019/S-BIAD1661, https://www.ebi.ac.uk/biostudies/bioimages/studies/S-BIAD1661
Dataset