Research output per year
Research output per year
Personal profile
Research overview
I'm a research fellow in Professor David Harrison's group, and my work primarily revolves around transcriptomic profiling of cancer. We utilise long-read sequencing techniques on various samples, including in-vitro cell lines, patient-derived tumouroids, and biopsies. Our particular focus lies in understanding drug-induced changes to RNA regulation within cancer cells. Employing various approaches including spatial transcriptomics and multiplex protein analysis, we aim to understand the RNA regulatory impact on protein expression and cellular phenotype.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Research output
- 7 Article
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Transcription factor NFE2L1 decreases in glomerulonephropathies after podocyte damage
Elshani, M., Um, I. H., Leung, S., Reynolds, P. A., Chapman, A., Kudsy, M. & Harrison, D. J., 29 Aug 2023, In: Cells. 12, 17, 2165.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
NUC-7738 regulates β-catenin signalling resulting in reduced proliferation and self-renewal of AML cells
Shahid, M. A., Um, I. H., Elshani, M., Zhang, Y. & Harrison, D. J., 15 Dec 2022, In: PLoS ONE. 17, 12, 13 p., e0278209.Research output: Contribution to journal › Article › peer-review
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Spatial analysis of NQO1 in non-small cell lung cancer shows its expression is independent of NRF1 and NRF2 in the tumor microenvironment
Kaghazchi, B., Um, I. H., Elshani, M., Read, O. J. & Harrison, D. J., 8 Nov 2022, In: Biomolecules. 12, 11, 16 p., 1652.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial
Schwenzer, H., De Zan, E., Elshani, M., van Stiphout, R., Kudsy, M., Morris, J., Ferrari, V., Um, I. H., Chettle, J., Kazmi, F., Campo, L., Easton, A., Nijman, S., Serpi, M., Symeonides, S., Plummer, R., Harrison, D. J., Bond, G. & Blagden, S. P., 8 Sept 2021, (E-pub ahead of print) In: Clinical Cancer Research. Early, 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Tissue-specific immunopathology in fatal COVID-19
ICECAP consortium, Dorward, D. A., Russell, C. D., Um, I. H., Elshani, M., Armstrong, S. D., Penrice-Randal, R., Millar, T., Lerpiniere, C. E. B., Tagliavini, G., Hartley, C. S., Randle, N. P., Gachanja, N. N., Potey, P. M. D., Dong, X., Anderson, A. M., Campbell, V. L., Duguid, A. J., Al Qsous, W. & BouHaidar, R. & 9 others, , 15 Jan 2021, In: American Journal of Respiratory and Critical Care Medicine. 203, 2, p. 192-201Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Podocyte injury elicits loss and recovery of cellular forces (dataset)
Haley, K. (Creator), Kronenberg, N. M. (Creator), Liehm, P. (Creator), Elshani, M. (Creator), Bell, C. (Creator), Harrison, D. J. (Creator), Gather, M. C. (Creator) & Reynolds, P. A. (Creator), University of St Andrews, 29 Jun 2018
DOI: 10.17630/c1c23356-7740-4901-b965-c9ed59c2dffe
Dataset
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Thesis
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The NFE2L1 transcription factor is a key modulator of the stress response in podocytes
Elshani, M. (Author), Harrison, D. J. (Supervisor) & Reynolds, P. A. (Supervisor), 17 Jun 2022Student thesis: Doctoral Thesis (PhD)