Personal profile

Profile Keywords

Epithelia; Ion/Solute Transport; Hormones; Renal Physiology; Molecular and Cellular Physiology

Research overview

The kidneys play a critical role in maintaining electrolyte homeostasis within the body. The regulation of sodium balance in particular maintains our circulating volume within narrow parameters and importantly contributes to the long-term control of blood pressure. Transport of electrolytes occurs via a number of different ion channels and transporters expressed at the surface of the epithelial cells lining the tubules of the nephron. Within the distal nephron, these processes are under strict regulation by a plethora of hormones and bioactive factors which can rapidly alter ion transport in response to physiological and pathophysiological challenges. Dysfunction of these transport processes and their regulation give rise to electrolyte disorders as well as dysregulated arterial blood pressure.

Our lab focuses on understanding the molecular mechanisms which underpin hormonal control of epithelial ion transport in the distal nephron in both health and disease. We combine electrophysiological methods with cutting edge molecular techniques to investigate receptor binding and translocation; intracellular signalling cascades; as well as subsequent modulation of ion transport, with a particular focus on Na+ transport via the epithelial sodium channel (ENaC).

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Postgraduate Certificate in Academic Practice (PgCAP), Edinburgh University

Award Date: 1 Nov 2019

Doctor of Philosophy, The signalling pathways allowing hormonal regulation of Na+ transport in murine collecting duct cells, University of Dundee

Award Date: 2 Dec 2010

Bachelor of Science, BSc (Hons) Biomedical Sciences - Physiology, University of Aberdeen

Award Date: 1 Jul 2006

External positions

Steering Committee - Epithelial Transport Group, American Physiological Society

Conferences Committee, The Physiological Society

The Journal of Physiology - Editorial Board, The Physiological Society


  • QP Physiology
  • Epithelia
  • Ion Transport
  • Intracellular Signalling
  • Renal Physiology


Dive into the research topics where Morag Mansley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or