Personal profile
Research overview
Asymmetric synthesis; Homogeneous catalysis; Greener Synthetic methodology; mechanism-led catalyst design.
Research interests
1. Asymmetric catalysis Asymmetric synthesis has developed into one of the most important fields of modern chemistry. The most efficient method to prepare an enantiomerically pure compound is to use a tiny amount of a chiral catalyst to mediate an asymmetric transformation. We are interested in developing new families of catalysts and uncovering new reactivity in this area. We are particularly keen to develop reactions that have the right characteristics for larger scale applicaiton should good enough catalysts be developed.
2. Catalytic Synthesis We are also interested in using new and known catalysts to devise improved, selective syntheses of important intermediates for fine chemicals, pharmaceuticals etc.
3. Catalyst design: Using physical Organic Chemistry approaches to understand how catalysts work, and improve the performance of catalysts for important reactions.
4. Greener Organic Chemistry enables by Catalysis: Probably underpinning all these projects is an aim to develop more environmentally benign approach to important chemicals.
Industrial relevance
Much of our work is aimed at producing new catalysts for reactions that could be operated in industrial scale synthesis of fine or bulk chemicals. There have been research collaborations with a variety of companies in most sectors of the chemical industry.
Academic/Professional Qualification
BSc (Hons), University of Bath; PhD, University of Bath; FRSC
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 7 Affordable and Clean Energy
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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High iso aldehyde selectivity in the hydroformylation of short-chain alkenes
Iu, L., Fuentes, J. A., Janka, M., Fontenot, K. J. & Clarke, M. L., 11 Feb 2019, In: Angewandte Chemie International Edition. 58, 7, p. 2120-2124 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A bifunctional MOF catalyst containing metal-phosphine and Lewis acidic active sites
Prasad, R. R. R., Dawson, D. M., Cox, P. A., Ashbrook, S. E., Wright, P. A. & Clarke, M. L., 12 Oct 2018, In: Chemistry - A European Journal. 24, 57, p. 15309-15318Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Understanding a hydroformylation catalyst that produces branched aldehydes from alkyl alkenes
Dingwall, P., Fuentes, J. A., Crawford, L., Slawin, A. M. Z., Buehl, M. & Clarke, M. L., 8 Nov 2017, In: Journal of the American Chemical Society. 139, 44, p. 15921–15932Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Rational design of a facially coordinating P,N,N ligand for manganese-catalysed enantioselective hydrogenation of cyclic ketones
Oates, C. L., Goodfellow, A. S., Bühl, M. & Clarke, M. L., 16 Jan 2023, In: Angewandte Chemie International Edition. 62, 3, 7 p., e202212479.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A highly active manganese catalyst for enantioselective ketone and ester hydrogenation
Widegren, M. B., Harkness, G. J., Slawin, A. M. Z., Cordes, D. B. & Clarke, M. L., 8 May 2017, In: Angewandte Chemie International Edition. 56, 21, p. 5825-5828 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Data underpinning - Manganese catalyzed hydrogenation of enantiomerically pure esters
Widegren, M. B. (Creator) & Clarke, M. L. (Supervisor), University of St Andrews, 20 Apr 2018
DOI: 10.17630/29308cf7-b6b6-4b1b-809b-a12fe91b250f
Dataset
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Underpinning data: High iso aldehyde selectivity in the hydroformylation of short-chain alkenes
Fuentes García, J. A. (Creator), Clarke, M. L. (Creator), Iu, L. (Creator), Janka, M. E. (Creator) & Fontenot, K. J. (Creator), University of St Andrews, 25 Jan 2019
DOI: 10.17630/6ed96377-ab54-4fb3-98c9-d2a5bc4d333e
Dataset
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Underpinning data: CO-free Enantioselective Hydroformylation of Functionalised Alkenes: Using a Dual Catalyst System to give Improved Selectivity and yield
Pittaway, R. (Contributor), Dingwall, P. (Contributor), Fuentes García, J. A. (Creator) & Clarke, M. L. (Creator), University of St Andrews, 21 Apr 2020
DOI: 10.17630/e491713d-9de2-4fa4-8853-4d7ce2656cfd
Dataset
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New Catalysts for branched selective hydroformylation of alkenes (thesis data)
Iu, L. (Creator) & Clarke, M. L. (Supervisor), University of St Andrews, 6 Dec 2029
DOI: 10.17630/e5effcce-39e1-41ac-9c66-3082f70a62e4, http://hdl.handle.net/10023/17068
Dataset: Thesis dataset
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A Bifunctional MOF catalyst containing Metal-Phosphine and Lewis Acidic Active Sites (dataset)
R R, R. P. (Creator), Dawson, D. M. (Creator), Cox, P. A. (Creator), Ashbrook, S. E. M. (Creator), Wright, P. A. (Creator) & Clarke, M. L. (Creator), University of St Andrews, 2 Oct 2018
DOI: 10.17630/1d50d4fd-7d29-4f2a-89ff-f9091f6bd4ea
Dataset
File
Projects
- 23 Finished
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Towards commercial application: Towards commercial application of manganese catalysts for sustainable chemical synthesis: Phase 2
Clarke, M. (PI)
1/08/21 → 28/02/22
Project: Standard
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Manganese catalysts: Towards commercial application of manganese catalysts for sustainable chemical analysis
Clarke, M. (PI)
15/02/18 → 28/02/19
Project: Standard
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IAA 2017-2020 M Clarke: Phosphacycles for Hydroformylation catalysis.
Clarke, M. (PI)
1/06/17 → 31/10/17
Project: Standard
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Phosphacycles for Hydroformylation: Phosphacycles for Hydroformylation catalysis
Clarke, M. (PI)
1/01/16 → 31/03/17
Project: Standard
Activities
- 3 Membership of research network
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EPSRC review College (External organisation)
Clarke, M. (Participant)
2006 → …Activity: Membership types › Membership of research network
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Royal Society of Chemistry (External organisation)
Clarke, M. (Participant)
2005 → …Activity: Membership types › Membership of research network
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Integrated Research in European Network of Excellence, IDECAT (External organisation)
Clarke, M. (Participant)
2005 → …Activity: Membership types › Membership of research network
Prizes
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Royal Society of Chemistry Higginbottom Award 2010
Clarke, M. (Recipient), 2010
Prize: Prize (including medals and awards)
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Winner of the Royal Society of Chemistry, Meldola award.
Clarke, M. (Recipient), 2005
Prize: Prize (including medals and awards)