Research output per year
Research output per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Magnus Stephen Alphey is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Research output
- 13 Article
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Crystal structure, steady-state and pre-steady-state kinetics of Acinetobacter baumannii ATP phosphoribosyltransferase
Read, B., Cadzow, A., Alphey, M. S., Mitchell, J. B. O. & da Silva, R. G., 16 Jan 2024, In: Biochemistry. 63, 2, p. 230-240 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Canonical binding of Chaetomium thermophilum DNA polymerase δ/ζ subunit PolD3 and flap endonuclease Fen1 to PCNA
Alphey, M. S., Wolford, C. & MacNeill, S., 18 Dec 2023, In: Frontiers in Molecular Biosciences. 10, 9 p., 1320648.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation
Fisher, G., Corbella, M., Alphey, M. S., Nicholson, J., Read, B., Kamerlin, S. C. L. & da Silva, R. G., 9 Dec 2022, In: Nature Communications. 13, 15 p., 7607.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Non‐canonical binding of the Chaetomium thermophilum PolD4 N‐terminal PIP motif to PCNA involves Q‐pocket and compact 2‐fork plug interactions but no 310 helix
Yang, D., Alphey, M. S. & MacNeill, S., 22 Aug 2022, (E-pub ahead of print) In: FEBS Journal. Early View, 14 p., 16590.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Next generation glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: an extended SAR study to direct future design
Xiao, G., Alphey, M. S., Tran, F., Pirrie, L., Milbeo, P., Zhou, Y., Bickel, J. K., Kempf, O., Kempf, K., Naismith, J. H. & Westwood, N. J., 15 Nov 2021, In: Bioorganic & Medicinal Chemistry. 50, 116477.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation (dataset 2)
Fisher, G. (Creator), Corbella, M. (Creator), Alphey, M. S. (Creator), Nicholson, J. (Creator), Read, B. (Creator) & Guimaraes da Silva, R. (Creator), Zenodo, 2022
Dataset
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ATP phosphoribosyltransferase (HisZG ATPPRT) from Psychrobacter arcticus (PDB entry 5M8H)
Stroek, R. (Creator), Ge, Y. (Creator), Talbot, P. D. (Creator), Glok, M. K. (Creator), Bernas, K. E. (Creator), Thomson, C. M. (Creator), Gould, E. R. (Creator), Alphey, M. S. (Creator), Liu, H. (Creator), Florence, G. J. (Creator), Naismith, J. H. (Creator) & Guimaraes da Silva, R. (Creator), Protein Data Bank (PDB), 6 Sept 2017
DOI: 10.2210/pdb5M8H/pdb, http://dx.doi.org/10.2210/pdb5m8h/pdb
Dataset
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PCNA from Chaetomium thermophilum in complex with Fen1 peptide
Alphey, M. S. (Creator), Wolford, C. (Creator) & MacNeill, S. (Creator), RCSB-PDB, 2023
DOI: 10.2210/pdb8q7i/pdb, https://www.rcsb.org/structure/8Q7I
Dataset
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PCNA from Chaetomium thermophilum in complex with PolD3 peptide
Alphey, M. S. (Creator), Wolford, C. (Creator) & MacNeill, S. (Creator), RCSB-PDB, 2023
DOI: 10.2210/pdb8P9O/pdb, https://www.rcsb.org/structure/8P9O
Dataset
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Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation (dataset)
Alphey, M. S. (Creator), Read, B. (Creator) & Guimaraes da Silva, R. (Creator), Protein Data Bank archive (PDB), 2022
DOI: 10.2210/pdb7Z8U/pdb, https://www.rcsb.org/structure/6FCT and 2 more links, https://www.rcsb.org/structure/6FU2, https://www.rcsb.org/structure/7Z6R (show fewer)
Dataset