Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Research output
- 14 Article
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High-throughput screening of potent drug-like molecules targeting 17β-HSD10 for the treatment of Alzheimer's disease and cancer
Aitken, L., Baillie, G., Pannifer, A., Morrison, A., Major, L. L., Alphey, M. S., Sethi, R., Timmerman, M., Robinson, J., Riley, J., Shishikura, Y., Koekemoer, L., Von Delft, F., Rutjes, H., Read, K., Jones, P. S., McElroy, S. P., Smith, T. K. & Gunn-Moore, F. J., 18 Jun 2025, (E-pub ahead of print) In: ACS Chemical Biology. ASAP, p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
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Crystal structure, steady-state and pre-steady-state kinetics of Acinetobacter baumannii ATP phosphoribosyltransferase
Read, B., Cadzow, A., Alphey, M. S., Mitchell, J. B. O. & da Silva, R. G., 16 Jan 2024, In: Biochemistry. 63, 2, p. 230-240 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Canonical binding of Chaetomium thermophilum DNA polymerase δ/ζ subunit PolD3 and flap endonuclease Fen1 to PCNA
Alphey, M. S., Wolford, C. & MacNeill, S., 18 Dec 2023, In: Frontiers in Molecular Biosciences. 10, 9 p., 1320648.Research output: Contribution to journal › Article › peer-review
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Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation
Fisher, G., Corbella, M., Alphey, M. S., Nicholson, J., Read, B., Kamerlin, S. C. L. & da Silva, R. G., 9 Dec 2022, In: Nature Communications. 13, 15 p., 7607.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Non‐canonical binding of the Chaetomium thermophilum PolD4 N‐terminal PIP motif to PCNA involves Q‐pocket and compact 2‐fork plug interactions but no 310 helix
Yang, D., Alphey, M. S. & MacNeill, S., 22 Aug 2022, (E-pub ahead of print) In: FEBS Journal. Early View, 14 p., 16590.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation (dataset)
Alphey, M. S. (Creator), Read, B. (Creator) & Guimaraes da Silva, R. (Creator), Protein Data Bank archive (PDB), 2022
DOI: 10.2210/pdb7Z8U/pdb, https://www.rcsb.org/structure/6FCT and 2 more links, https://www.rcsb.org/structure/6FU2, https://www.rcsb.org/structure/7Z6R (show fewer)
Dataset
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Mapping the structural path for allosteric inhibition of a short-form ATP phosphoribosyltransferase by histidine (dataset)
Alphey, M. S. (Creator) & Guimaraes da Silva, R. (Creator), Protein Data Bank (PDB), 2 Sept 2019
DOI: 10.1021/acs.biochem.9b00282
Dataset
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PCNA from Chaetomium thermophilum in complex with PolD3 peptide
Alphey, M. S. (Creator), Wolford, C. (Creator) & MacNeill, S. (Creator), RCSB-PDB, 2023
DOI: 10.2210/pdb8P9O/pdb, https://www.rcsb.org/structure/8P9O
Dataset
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Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation (dataset 2)
Fisher, G. (Creator), Corbella, M. (Creator), Alphey, M. S. (Creator), Nicholson, J. (Creator), Read, B. (Creator) & Guimaraes da Silva, R. (Creator), Zenodo, 2022
Dataset
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ATP phosphoribosyltransferase (HisZG ATPPRT) from Psychrobacter arcticus (PDB entry 5M8H)
Stroek, R. (Creator), Ge, Y. (Creator), Talbot, P. D. (Creator), Glok, M. K. (Creator), Bernas, K. E. (Creator), Thomson, C. M. (Creator), Gould, E. R. (Creator), Alphey, M. S. (Creator), Liu, H. (Creator), Florence, G. J. (Creator), Naismith, J. H. (Creator) & Guimaraes da Silva, R. (Creator), Protein Data Bank (PDB), 6 Sept 2017
DOI: 10.2210/pdb5M8H/pdb, http://dx.doi.org/10.2210/pdb5m8h/pdb
Dataset
Activities
- 1 Other external non-academic engagement
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Career Fair at St Peter and St Pauls Primary School in Dundee
Melo Czekster, C. (Consultant), Sleeman, J. E. (Consultant), Loth, A. (Consultant), Alphey, M. S. (Consultant), Russell, D. J. (Consultant) & Penedo-Esteiro, J. C. (Consultant)
4 Oct 2018Activity: Consultancy types › Other external non-academic engagement