Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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High-throughput screening of potent drug-like molecules targeting 17β-HSD10 for the treatment of Alzheimer's disease and cancer
Aitken, L., Baillie, G., Pannifer, A., Morrison, A., Major, L. L., Alphey, M. S., Sethi, R., Timmerman, M., Robinson, J., Riley, J., Shishikura, Y., Koekemoer, L., Von Delft, F., Rutjes, H., Read, K., Jones, P. S., McElroy, S. P., Smith, T. K. & Gunn-Moore, F. J., 18 Jun 2025, (E-pub ahead of print) In: ACS Chemical Biology. ASAP, p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
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Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation
Benek, O., Vaskova, M., Miskerikova, M., Schmidt, M., Andrys, R., Rotterova, A., Skarka, A., Hatlapatkova, J., Karasova, J. Z., Medvecky, M., Hroch, L., Vinklarova, L., Fisar, Z., Hroudova, J., Handl, J., Capek, J., Rousar, T., Kobrlova, T., Dolezal, R. & Soukup, O. & 3 others, , 5 Oct 2023, In: European Journal Of Medicinal Chemistry. 258, 18 p., 115593.Research output: Contribution to journal › Article › peer-review
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Willin/FRMD6 mediates mitochondrial dysfunction relevant to neuronal Aβ toxicity
Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 6 Oct 2022, In: Cells. 11, 19, 27 p., 3140.Research output: Contribution to journal › Article › peer-review
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Willin/FRMD6: a multi-functional neuronal protein associated with Alzheimer’s disease
Chen, D., Yu, W., Aitken, L. & Gunn-Moore, F. J., 4 Nov 2021, In: Cells. 10, 11, 27 p., 3024.Research output: Contribution to journal › Review article › peer-review
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Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17β-HSD10 with implications to Alzheimer’s disease treatment
Schmidt, M., Benek, O., Vinklarova, L., Hrabinova, M., Zemanova, L., Chribek, M., Kralova, V., Hroch, L., Dolezal, R., Lycka, A., Prchal, L., Jun, D., Aitken, L., Gunn-Moore, F., Kuca, K. & Musilek, K., 17 Mar 2020, In: International Journal of Molecular Sciences. 21, 6, 26 p., 2059.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Data underpinning: Novel benzothiazole-based ureas as 17β-HSD10 inhibitors, a potential Alzheimer’s disease treatment
Aitken, L. (Creator), Benek, O. (Contributor), McKelvie, B. (Contributor), Hughes, R. (Contributor), Hroch, L. (Contributor), Major, L. L. (Creator), kuca, K. (Contributor), Smith, T. K. (Supervisor), Musilek, K. (Contributor) & Gunn-Moore, F. J. (Supervisor), University of St Andrews, 2018
DOI: 10.17630/a9bb5ff9-b6cf-4175-9840-961d4c47651a
Dataset
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Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function (dataset)
Cheng, Y. (Creator), Buchan, M. (Creator), Vitanova, K. (Creator), Aitken, L. (Creator), Gunn-Moore, F. J. (Creator), Ramsay, R. R. (Creator) & Doherty, G. H. (Creator), University of St Andrews, 2019
DOI: 10.17630/5702d258-6712-4b72-bc3d-fcb244c90313
Dataset
File
Projects
- 2 Finished
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ISSF3 Laura Aitken ext - translation: ISSF3 - Laura Aitken extension
Aitken, L. (PI)
1/04/19 → 30/09/19
Project: Standard
Activities
- 1 Participation in or organising a public festival/exhibition/event
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Doors Open @ Computer Science 2026
Hoffmann, R. (Chair of organising committee), Morrison, D. (Member of organising committee), Ross, K. (Member of organising committee), Ardati, A. A. (Participant), Dearle, A. (Participant), Connor, R. (Participant), Claydon, B. (Participant), Sturdee, M. (Participant), Miguel, A. R. (Participant), Manataki, A. (Participant), Myles, C. G. G. (Participant), Harris-Birtill, D. C. C. (Participant), Balasubramaniam, D. (Participant), Brady, E. C. (Participant), Ye, J. (Participant), Clarke, L. (Participant), Young, M. (Participant), Chang, M. S. (Participant), Akgun, O. (Participant), Gent, I. P. (Participant), Jefferson, C. A. (Participant), Konovalov, O. (Participant), Nickson, Z. (Participant), Woodville-Price, T. (Participant), Donnelly, P. (Participant), To, S. H. (Participant), Spink, T. (Participant), Ren, Q. (Participant), McKechnie, M. (Participant), Redina, P. (Participant), Martin, N. (Participant), Mccurry, A. (Participant), Donaldson, D. (Participant), McCann, P. (Participant), Crowe, S. (Participant), Michalovits, S. (Participant), Terry, S. (Participant), Rosales Sanabria, A. (Participant), Nowshadi, Z. A. (Participant), Lin, Q. (Participant), Fogwill, M. (Participant), Sullivan, J. (Participant), Cardwell, K. (Participant), Kerlaff, K. (Participant), Chan, T. (Participant), Gronda Garrigues, P. (Participant), Janik, V. (Participant), Oswald, J. (Participant), Ellis, A. (Participant), Novozhylova, M. (Participant), Chub, O. (Participant), Shevchenko, V. (Participant), Boiar, Y. (Participant), Schrempf, P. (Participant), Murray, M. (Participant), Nederhof, M. (Participant), Dobson, S. (Participant), Johnston, A. (Participant), Aitken, L. (Participant), Kirby, G. (Participant), Babazadeh, K. (Participant), Hansen, T. E. (Participant), Telford, H. (Participant), Vesely, K. (Participant), Tronciu, V. (Participant), Huica, T. (Participant), Soe, S. (Participant), Abdul Khadeer, M. S. (Participant), Silva De Oliveira, R. (Participant), McGowan, J. (Participant), Doshi, A. (Participant), Loughney, J. P. (Participant) & Boyd, K. (Participant)
28 Apr 2026Activity: Participating in or organising an event types › Participation in or organising a public festival/exhibition/event