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Juan Varela

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Juan Varela

Dr

 https://orcid.org/0000-0003-1901-1378

  • School of Physics & Astronomy, Physical Science Building, North Haugh, St Andrews, KY16 9SS, UK

Accepting Postgraduate Research Students

Personal profile

Research overview

Juan studied physics in Uruguay and did his PhD in Ireland at the Centre for Bio-Nano Interactions, University College Dublin. He subsequently did a postdoc at the Interdisciplinary Institute for Neurosciences in Bordeaux (France), and a second postdoc in neurodegeneration at the Department of Chemistry at the University of Cambridge (UK). Juan established his research group at the University of St Andrews funded by a European Research Council Starting Grant. His main research interests are the use of nanotechnology and single-molecule imaging to understand and cure neurodegenerative diseases. Visit our lab website for research updates and opportunities: https://neurophotonics.wp.st-andrews.ac.uk/

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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  • Divergent toxicity mechanisms of amyloid-beta aggregates arising from a single aggregation reaction

    Metodieva, V., Marchese, S., Esposito, P., Danial, J. S. H., Di Falco, A., De, S., Klenerman, D. & Varela, J. A., 28 Jul 2026, In: Cell Reports. 45, 7, 22 p., 117595.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • HAPLN2 forms aggregates and promotes microglial inflammation during brain aging in mice

    Watanabe, A., Hirayama, S., Kominato, I., Marchese, S., Esposito, P., Metodieva, V., Kimura, T., Kameda, H., Sano, T., Takao, M., Takatori, S., Koike, M., Varela, J. A., Tomita, T. & Murata, S., 14 Aug 2025, In: PLoS Biology. 23, 8, e3003006.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity

    Resnick, S. J., Qamar, S., Krishna, P., Korobeynikov, V., Ausserwoger, H., Miller, A., Esposito, P., Varela, J. A., Sheng, J., Huang, L. H., Nixon-Abell, J., Melore, S., Chung, C. W., Läubli, N. F., Kapsiani, S., Li, X., Wang, J., Zhang, N., Alam, M. M. & Burguete, A. S. & 11 others, Swayne, T. C., Chen, Y., Liao, Y.-C., Shneider, N. A., Vendruscolo, M., Knowles, T. P. J., Kaminski, C. F., Ruggeri, F. S., Kaminski Schierle, G. S., St George-Hyslop, P. & Chavez, A., 1 Nov 2025, In: Nature Communications. 16, p. 1-27 27 p., 10285.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Single-molecule imaging of aquaporin-4 array dynamics in astrocytes

    Zepernick, A.-L., Metodieva, V., Pelegrina-Hidalgo, N., Lippert, A. H., Horrocks, M. H. & Varela, J. A., 21 May 2024, In: Nanoscale. 16, 19, p. 9576-9582 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Structure-specific amyloid precipitation in biofluids

    Rodrigues, M., Bhattacharjee, P., Brinkmalm, A., Do, D. T., Pearson, C. M., De, S., Ponjavic, A., Varela, J. A., Kulenkampff, K., Baudrexel, I., Emin, D., Ruggeri, F. S., Lee, J. E., Carr, A. R., Knowles, T. P. J., Zetterberg, H., Snaddon, T. N., Gandhi, S., Lee, S. F. & Klenerman, D., Sept 2022, In: Nature Chemistry. 14, 9, p. 1045-1056 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
View all 26 research outputs