Research output per year
Research output per year
- 35 results
Search results
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2025
A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection
Yeap, H. W., Goh, G. R., Rosli, S. N., Pung, H. S., Giogha, C., Eng, V. V., Pearson, J. S., Hartland, E. L. & Chen, K. W., 24 Mar 2025, (E-pub ahead of print) In: EMBO Journal.Research output: Contribution to journal › Article › peer-review
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2024
Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death
Deerain, J. M., Aktepe, T. E., Trenerry, A. M., Ebert, G., Hyde, J. L., Charry, K., Edgington-Mitchell, L., Xu, B., Ambrose, R. L., Sarvestani, S. T., Lawlor, K. E., Pearson, J. S., White, P. A. & Mackenzie, J. M., Jan 2024, In: Virology. 589, p. 1-12 12 p., 109921.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Norovirus-mediated translation repression promotes macrophage cell death
Aktepe, T. E., Deerain, J. M., Hyde, J. L., Fritzlar, S., Mead, E. M., Montoya, J. C., Hachani, A., Pearson, J. S., White, P. A. & Mackenzie, J. M., 3 Sept 2024, In: PLoS Pathogens. 20, 9, p. 1-23 23 p., e1012480.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2023
A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation
Speir, M., Tye, H., Gottschalk, T. A., Simpson, D. S., Djajawi, T. M., Deo, P., Ambrose, R. L., Conos, S. A., Emery, J., Abraham, G., Pascoe, A., Hughes, S. A., Weir, A., Hawkins, E. D., Kong, I., Herold, M. J., Pearson, J. S., Lalaoui, N., Naderer, T. & Vince, J. E. & 1 others, , 6 Nov 2023, In: EMBO Reports. 24, 11, 19 p., e56865.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
Garnish, S. E., Martin, K. R., Kauppi, M., Jackson, V. E., Ambrose, R., Eng, V. V., Chiou, S., Meng, Y., Frank, D., Tovey Crutchfield, E. C., Patel, K. M., Jacobsen, A. V., Atkin-Smith, G. K., Di Rago, L., Doerflinger, M., Horne, C. R., Hall, C., Young, S. N., Cook, M. & Athanasopoulos, V. & 11 others, , 28 Sept 2023, In: Nature Communications. 14, 17 p., 6046.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency
Hughes, S. A., Lin, M., Weir, A., Huang, B., Xiong, L., Chua, N. K., Pang, J., Santavanond, J. P., Tixeira, R., Doerflinger, M., Deng, Y., Yu, C. H., Silke, N., Conos, S. A., Frank, D., Simpson, D. S., Murphy, J. M., Lawlor, K. E., Pearson, J. S. & Silke, J. & 10 others, , 1 Mar 2023, In: EMBO Journal. 42, 5, p. 1-21 21 p., e110468.Research output: Contribution to journal › Article › peer-review
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2022
Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death
Liu, L., Sandow, J. J., Leslie Pedrioli, D. M., Samson, A. L., Silke, N., Kratina, T., Ambrose, R. L., Doerflinger, M., Hu, Z., Morrish, E., Chau, D., Kueh, A. J., Fitzibbon, C., Pellegrini, M., Pearson, J. S., Hottiger, M. O., Webb, A. I., Lalaoui, N. & Silke, J., 1 May 2022, In: Science Advances. 8, 19, eabh2332.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli
Pollock, G. L., Grishin, A. M., Giogha, C., Gan, J., Oates, C. V., McMillan, P. J., Gaeta, I., Tyska, M. J., Pearson, J. S., Scott, N. E., Cygler, M. & Hartland, E. L., 23 Aug 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 34, p. 1-11 11 p., e2204332119.Research output: Contribution to journal › Article › peer-review
Open Access -
Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death
Frank, D., Garnish, S. E., Sandow, J. J., Weir, A., Liu, L., Clayer, E., Meza, L., Rashidi, M., Cobbold, S. A., Scutts, S. R., Doerflinger, M., Anderton, H., Lawlor, K. E., Lalaoui, N., Kueh, A. J., Eng, V. V., Ambrose, R. L., Herold, M. J., Samson, A. L. & Feltham, R. & 4 others, , 15 Jul 2022, In: iScience. 25, 7, p. 1-28 28 p., 104632.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2021
An acetate-yielding diet imprints an immune and anti-microbial programme against enteric infection
Yap, Y. A., McLeod, K. H., McKenzie, C. I., Gavin, P. G., Davalos-Salas, M., Richards, J. L., Moore, R. J., Lockett, T. J., Clarke, J. M., Eng, V. V., Pearson, J. S., Hamilton-Williams, E. E., Mackay, C. R. & Mariño, E., 15 Jan 2021, In: Clinical and Translational Immunology. 10, 1, p. 1-23 23 p., e1233.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia
Ingle, D. J., Ambrose, R. L., Baines, S. L., Duchene, S., Gonçalves da Silva, A., Lee, D. Y. J., Jones, M., Valcanis, M., Taiaroa, G., Ballard, S. A., Kirk, M. D., Howden, B. P., Pearson, J. S. & Williamson, D. A., 9 Aug 2021, In: Nature Communications. 12, 1, p. 4786Research output: Contribution to journal › Article › peer-review
Open Access -
NleB2 from enteropathogenic Escherichia coli is a novel arginine-glucose transferase effector
Giogha, C., Scott, N. E., Lung, T. W. F., Pollock, G. L., Harper, M., Goddard-Borger, E. D., Pearson, J. S. & Hartland, E. L., 16 Jun 2021, In: PLoS Pathogens. 17, 6, e1009658.Research output: Contribution to journal › Article › peer-review
Open Access -
Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2′-O-methyl gapmer oligonucleotides
Valentin, R., Wong, C., Alharbi, A. S., Pradeloux, S., Morros, M. P., Lennox, K. A., Ellyard, J. I., Garcin, A. J., Ullah, T. R., Kusuma, G. D., Pépin, G., Li, H. M., Pearson, J. S., Ferrand, J., Lim, R., Veedu, R. N., Morand, E. F., Vinuesa, C. G., Behlke, M. A. & Gantier, M. P., 21 Jun 2021, In: Nucleic Acids Research. 49, 11, p. 6082-6099 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Shigella shuts down the pyrop-technic show
Giogha, C. & Pearson, J. S., 13 Oct 2021, In: Cell Host and Microbe. 29, 10, p. 1473-1476 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
Vijayaraj, S. L., Feltham, R., Rashidi, M., Frank, D., Liu, Z., Simpson, D. S., Ebert, G., Vince, A., Herold, M. J., Kueh, A., Pearson, J. S., Dagley, L. F., Murphy, J. M., Webb, A. I., Lawlor, K. E. & Vince, J. E., 11 May 2021, In: Nature Communications. 12, p. 1-16 16 p., 2713.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2020
Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection
Doerflinger, M., Deng, Y., Whitney, P., Salvamoser, R., Engel, S., Kueh, A. J., Tai, L., Bachem, A., Gressier, E., Geoghegan, N. D., Wilcox, S., Rogers, K. L., Garnham, A. L., Dengler, M. A., Bader, S. M., Ebert, G., Pearson, J. S., De Nardo, D., Wang, N. & Yang, C. & 8 others, , 15 Sept 2020, In: Immunity. 53, 3, p. 533-547.e7Research output: Contribution to journal › Article › peer-review
Open Access -
The Salmonella Effector SseK3 Targets Small Rab GTPases
Gan, J., Scott, N. E., Newson, J. P. M., Wibawa, R. R., Wong Fok Lung, T., Pollock, G. L., Ng, G. Z., van Driel, I., Pearson, J. S., Hartland, E. L. & Giogha, C., 19 Aug 2020, In: Frontiers in Cellular and Infection Microbiology. 10, 419.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways
Newson, J. P. M., Scott, N. E., Chung, I. Y. W., Lung, T. W. F., Giogha, C., Gan, J., Wang, N., Strugnell, R. A., Brown, N. F., Cygler, M., Pearson, J. S. & Hartland, E. L., 1 Jun 2019, In: Molecular and Cellular Proteomics. 18, 6, p. 1138-1156 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Distinct roles of the antiapoptotic effectors NleB and NleF from enteropathogenic Escherichia coli
Pollock, G. L., Oates, C. V. L., Giogha, C., Lung, T. W. F., Ong, S. Y., Pearson, J. S. & Hartland, E. L., 1 Apr 2017, In: Infection and Immunity. 85, 4, e01071-16.Research output: Contribution to journal › Article › peer-review
Open Access -
Down the rabbit hole: Is necroptosis truly an innate response to infection?
Pearson, J. S. & Murphy, J. M., Aug 2017, In: Cellular Microbiology. 19, 8, e12750.Research output: Contribution to journal › Article › peer-review
Open Access -
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
Pearson, J. S., Giogha, C., Mühlen, S., Nachbur, U., Pham, C. L. L., Zhang, Y., Hildebrand, J. M., Oates, C. V., Lung, T. W. F., Ingle, D., Dagley, L. F., Bankovacki, A., Petrie, E. J., Schroeder, G. N., Crepin, V. F., Frankel, G., Masters, S. L., Vince, J., Murphy, J. M. & Sunde, M. & 3 others, , 13 Jan 2017, In: Nature Microbiology. 2, 16258.Research output: Contribution to journal › Article › peer-review
Open Access -
The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD)
Scott, N. E., Giogha, C., Pollock, G. L., Kennedy, C. L., Webb, A. I., Williamson, N. A., Pearson, J. S. & Hartland, E. L., 20 Oct 2017, In: Journal of Biological Chemistry. 292, 42, p. 17337-17350 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The type III effector NleD from enteropathogenic Escherichia coli differentiates between host substrates p38 and JNK
Creuzburg, K., Giogha, C., Lung, T. W. F., Scott, N. E., Mühlen, S., Hartland, E. L. & Pearson, J. S., 2017, In: Infection and Immunity. 85, 2, e00620-16.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
Evolution of atypical enteropathogenic E. Coli by repeated acquisition of LEE pathogenicity island variants
Ingle, D. J., Tauschek, M., Edwards, D. J., Hocking, D. M., Pickard, D. J., Azzopardi, K. I., Amarasena, T., Bennett-Wood, V., Pearson, J. S., Tamboura, B., Antonio, M., Ochieng, J. B., Oundo, J., Mandomando, I., Qureshi, S., Ramamurthy, T., Hossain, A., Kotloff, K. L., Nataro, J. P. & Dougan, G. & 3 others, , 18 Jan 2016, In: Nature Microbiology. 1, 2, 15010.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of a distinct substrate-binding domain in the bacterial cysteine methyltransferase effectors NleE and OspZ
Zhang, Y., Mühlen, S., Oates, C. V., Pearson, J. S. & Hartland, E. L., 16 Sept 2016, In: Journal of Biological Chemistry. 291, 38, p. 20149-20162 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mutagenesis and functional analysis of the bacterial arginine glycosyltransferase effector NleB1 from enteropathogenic Escherichia coli
Wong Fok Lung, T., Giogha, C., Creuzburg, K., Ong, S. Y., Pollock, G. L., Zhang, Y., Fung, K. Y., Pearson, J. S. & Hartland, E. L., 1 May 2016, In: Infection and Immunity. 84, 5, p. 1346-1360 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic Escherichia coli
Giogha, C., Wong Fok Lung, T., Mühlen, S., Pearson, J. S. & Hartland, E. L., Dec 2015, In: Cellular Microbiology. 17, 12, p. 1766-1778 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2014
A surprising sweetener from enteropathogenic Escherichia coli
Pearson, J. S. & Hartland, E. L., 2014, In: Gut Microbes. 5, 6, p. 766-769 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation
Young, J. C., Clements, A., Lang, A. E., Garnett, J. A., Munera, D., Arbeloa, A., Pearson, J., Hartland, E. L., Matthews, S. J., Mousnier, A., Barry, D. J., Way, M., Schlosser, A., Aktories, K. & Frankel, G., 2014, In: Nature Communications. 5, p. 5887 1 p., 5887.Research output: Contribution to journal › Article › peer-review
Open Access -
The inflammatory response during enterohemorrhagic Escherichia coli infection
Pearson, J. S. & Hartland, E. L., 2014, In: Microbiology Spectrum. 2, 4, EHEC-0012-2013.Research output: Contribution to journal › Article › peer-review
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The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection
Pallett, M. A., Berger, C. N., Pearson, J. S., Hartland, E. L. & Frankel, G., 2014, In: Infection and Immunity. 82, 11, p. 4878-4888 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2013
A type III effector antagonizes death receptor signalling during bacterial gut infection
Pearson, J. S., Giogha, C., Ong, S. Y., Kennedy, C. L., Kelly, M., Robinson, K. S., Lung, T. W. F., Mansell, A., Riedmaier, P., Oates, C. V. L., Zaid, A., Mühlen, S., Crepin, V. F., Marches, O., Ang, C. S., Williamson, N. A., O'Reilly, L. A., Bankovacki, A., Nachbur, U. & Infusini, G. & 5 others, , 2013, In: Nature. 501, 7466, p. 247-251 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of the ospz promoter in shigella flexneri and its regulation by virb and h-ns
Basta, D. W., Pew, K. L., Immak, J. A., Park, H. S., Picker, M. A., Wigley, A. F., Hensley, C. T., Pearson, J. S., Hartland, E. L. & Wing, H. J., Jun 2013, In: Journal of Bacteriology. 195, 11, p. 2562-2572 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2011
A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation
Pearson, J. S., Riedmaier, P., Marchès, O., Frankel, G. & Hartland, E. L., Apr 2011, In: Molecular Microbiology. 80, 1, p. 219-230 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2010
The type III effectors NieE and NleB from enteropathogenic E. coli and Ospz from shigella block nuclear translocation of NF-κB p65
Newton, H. J., Pearson, J. S., Badea, L., Kelly, M., Lucas, M., Holloway, G., Wagstaff, K. M., Dunstone, M. A., Sloan, J., Whisstock, J. C., Kaper, J. B., Robins-Browne, R. M., Jans, D. A., Frankel, G., Phillips, A. D., Coulson, B. S. & Hartland, E. L., May 2010, In: PLoS Pathogens. 6, 5, p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
Open Access