Research output per year
Research output per year
Personal profile
Research overview
Novel ligand-gated ion channels in nerve cells.
Nerve cells communicate by releasing chemical messengers, often referred to as neurotransmitters. Some neurotransmitters exert fast effects (via ligand-gated ion channels) others slow effects (via enzyme coupled receptors). We have recently discovered fast actions of two transmitters hithertoo only thought to produce slow effects: a neuropeptide, FMRFamide, and dopamine. The channels directly gated by these substances are being studied in detail. The peptide gated channel (now cloned) is unique in showing a high selectivity for Na ions and also in being antagonised by another endogenous, related, peptide.
Industrial relevance
pharmaceutical industry;computing: development of software for electrophysiological work
Academic/Professional Qualification
D.Sc., University of Southampton; Ph.D., University of Southampton; B.Sc., University of Southampton; MRC Advisory Board; British Pharmacological Society; Physiological Society
-
Fast silencing reveals a lost role for reciprocal inhibition in locomotion
Moult, P. R., Cottrell, G. A. & Li, W., 9 Jan 2013, In: Neuron. 77, 1, p. 129-140 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Green laser light (532nm) activates a chloride current in the C1 neuron of Helix aspersa
Reece, P. J., Dholakia, K., Thomas, R. C. & Cottrell, G. A., 15 Mar 2008, In: Neuroscience Letters. 433, 3, p. 265-269 5 p.Research output: Contribution to journal › Article › peer-review
-
Green light activates some and inhibits other neurons of snail ganglia
Reece, P. J., Dholakia, K. & Cottrell, G. A., 2007, Acta Physiologica.Research output: Book/Report › Book
-
Domain near TM1 influences agonist and antagonist responses of peptide-gated Na(+) channels.
Cottrell, G. A., Jun 2005, In: Pflügers Archiv: European Journal of Physiology. 450, 3, p. 168-177 10 p.Research output: Contribution to journal › Article › peer-review
-
Activity modes and modulation of the peptide-gated Na(+) channel of Helix neurones
Green, K. & Cottrell, G. A., Mar 2002, In: Pflügers Archiv: European Journal of Physiology. 443, 5-6, p. 813-821 9 p.Research output: Contribution to journal › Article › peer-review
Projects
- 1 Finished
-
ConformationalStates of MembraneProtein: Conformational states of membranes proteins: Technology development for bioscience
Schiemann, O. (PI) & Cottrell, G. A. (CoI)
1/07/10 → 9/01/16
Project: Standard
Prizes
-
Fellow of the Royal Society of Edinburgh,
Cottrell, G. A. (Recipient), 1988
Prize: Election to learned society