Personal profile
Research overview
Lab website: http://ncm.wp.st-andrews.ac.uk/
The primary goal of the research in my laboratory is to provide a better understanding of the neural control of movement with a focus on motor systems of the brainstem and spinal cord. A detailed knowledge of the normal physiology of these systems is required to enable us to understand and ultimately treat neurodegenerative diseases and injuries which can afflict them. My lab's interests extend from the level of ion channels on individual neurons up to entire neuronal networks involved in motor behaviours. We study the physiology and anatomy of motor systems both in their normal 'healthy' state and when they are affected by conditions such as Motor Neuron Disease (MND).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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A cholinergic spinal pathway for the adaptive control of breathing
Lin, M., Calabrese, G., Incognito, A. V., Moore, M. T., Agarwal, A., Wilson, R. J. A., Zagoraiou, L., Sharples, S., Miles, G. & Philippidou, P., 26 Aug 2025, In: Cell Reports. 44, 8, p. 1-17 17 p., 116078.Research output: Contribution to journal › Article › peer-review
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Selective vulnerability of tripartite synapses in Amyotrophic Lateral Sclerosis
Broadhead, M. J., Bonthron, C., Waddington, J., Smith, W. V., Lopez, M. F., Burley, S., Valli, J., Zhu, F., Komiyama, N. H., Smith, C., Grant, S. G. N. & Miles, G. B., Apr 2022, In: Acta Neuropathologica. 143, 4, p. 471–486Research output: Contribution to journal › Article › peer-review
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Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development
Sharples, S. A. & Miles, G. B., 3 Dec 2021, In: eLife. 10, e71385.Research output: Contribution to journal › Article › peer-review
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Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability
Devlin, A.-C., Burr, K., Borooah, S., Foster, J. D., Cleary, E. M., Geti, I., Vallier, L., Shaw, C. E., Chandran, S. & Miles, G. B., 12 Jan 2015, In: Nature Communications. 6, 12 p., 5999.Research output: Contribution to journal › Article › peer-review
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A cluster of cholinergic premotor interneurons modulates mouse locomotor activity
Zagoraiou, L., Akay, T., Martin, J. F., Brownstone, R. M., Jessell, T. M. & Miles, G. B., 10 Dec 2009, In: Neuron. 64, 5, p. 645-662Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Modulation of Phrenic Respiratory Networks by Spinal Cholinergic Interneurons in the Intact and Lesioned Spinal Cord (thesis data)
Calabrese, G. B. (Creator), Miles, G. B. (Supervisor) & Sharples, S. A. (Supervisor), University of St Andrews, 30 Sept 2027
DOI: 10.17630/23e6adee-20fd-4304-8094-7805c36c0bee
Dataset: Thesis dataset
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Data underpinning - Arrays of Microscopic Organic LEDs for High Resolution Optogenetics
Gather, M. C. (Creator), Steude, A. (Creator), Witts, E. C. (Creator) & Miles, G. B. (Creator), University of St Andrews, 9 May 2016
DOI: 10.17630/d758df2c-78ee-482c-ae7f-af37b00fdb52
Dataset
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Photostimulation for in vitro optogenetics with high power blue organic light-emitting diodes (dataset)
Morton, A. (Creator), Murawski, C. (Creator), Deng, Y. (Creator), Keum, C. (Creator), Miles, G. B. (Creator), Tello, J. A. (Creator) & Gather, M. C. (Creator), University of St Andrews, 18 Jan 2019
DOI: 10.17630/80cbac70-227e-4564-9a8c-937257e9c49d
Dataset
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Long-term culture of SH-SY5Y neuroblastoma cells in the absence of neurotrophins: a novel model of neuronal ageing (dataset)
Strother, L. (Creator), Miles, G. B. (Creator), Holiday, A. R. (Creator), Cheng, Y. (Creator) & Doherty, G. H. (Creator), University of St Andrews, 2019
DOI: 10.17630/f901900e-bebc-472d-930d-01956ac508c6
Dataset
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Episodic rhythmicity is generated by a distributed neural network in the developing mammalian spinal cord
Milla-Cruz, J. J. (Creator), Lognon, A. P. (Creator), Tran, M. A. (Creator), Di Vito, S. A. (Creator), Löer, C. (Creator), Shonak, A. (Creator), Broadhead, M. (Creator), Miles, G. (Creator), Sharples, S. (Creator) & Whelan, P. J. (Creator), OSF, 2025
Dataset
Projects
- 20 Finished
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Tenovus Research Studentship: Harnessing spinal circuits to facilitate respiratory recovery following spinal cord injury in mice
Miles, G. (PI) & Sharples, S. (CoI)
27/11/20 → 26/11/23
Project: Studentship
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Judith Sleeman MND Scotland: Protein methylation as a mechanism for cellular damage in motor neurone disease
Sleeman, J. (PI) & Miles, G. (CoI)
Motor Neurone Disease Scotland
2/03/20 → 1/03/22
Project: Standard
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SPRINT-MND/MS: SPRINT MND/MS: Motor Neurone Disease and Multiple Sclerosis PhD Programme
Miles, G. (PI)
1/09/19 → 28/02/23
Project: Studentship
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Investigating ALS as a disease: Investigating ALS as a Disease of the Tripartite Synapse
Miles, G. (PI) & Broadhead, M. (CoI)
1/12/18 → 31/07/22
Project: Standard
Activities
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Invited talk "Revealing new therapeutic targets for Motor Neuron Disease (MND) using human stem cell-based technology" - MND Scotland LEARN event
Miles, G. (Speaker)
22 Oct 2025Activity: Talk or presentation types › Public lecture/debate/seminar
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Invited talk: "Spinal motor network dysfunction in a mouse model of ATP1A3-related dystonia" - 13th ATP1A3 in Disease Symposium
Miles, G. (Speaker)
16 Sept 2025Activity: Talk or presentation types › Invited talk
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Invited talk: "Local cholinergic interneurons modulate locomotor- and breathing-related motoneuron output" - Dalhousie University
Miles, G. (Speaker)
14 Jul 2025Activity: Talk or presentation types › Invited talk
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Invited talk: "Astrocytes of the spinal cord in health and disease: stars of the show or inadvertent showstoppers?" - University of Padova
Miles, G. (Speaker)
14 May 2025Activity: Talk or presentation types › Invited talk
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Invited talk "Investigating the role of astrocytes in the pathophysiology of Amyotrophic Lateral Sclerosis" - MND Scotland and My Name’5 Doddie Foundation CORE event
Miles, G. (Speaker)
3 Mar 2025Activity: Talk or presentation types › Public lecture/debate/seminar
Prizes
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7th International Paulo Gontijo Award in Medicine
Miles, G. B. (Recipient), 2015
Prize: Prize (including medals and awards)
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Teaching Award for Outstanding Dissertation Supervisor in the Science Faculty, University of St Andrews Student’s Association
Miles, G. B. (Recipient), 2010
Prize: Prize (including medals and awards)