Research output per year
Research output per year
Personal profile
Research overview
I have worked in both high and low income countries, accruing extensive experience in the management of infectious diseases, particularly tuberculosis (TB). I have successfully obtained research grant funding and completed a Wellcome Trust fellowship in Liverpool and Malawi, culminating in the award of a PhD from the University of Liverpool.
My research is targeted towards clinical therapeutics questions of global public health significance. Presentation and publication of my work has resulted in Young Investigator Awards and prizes at major international conferences. I have ongoing projects on the clinical pharmacology of anti-TB drugs, PK-PD modeling of responses to anti-microbial therapy and programmatic interventions to reduce mortality from infectious diseases in low resource settings.
I also have an interest in the acute management of infectious disease outbreaks, and supported the UKMed/NHS response to the Ebola Virus Disease epidemic in West Africa in 2015.
Research overview
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Year |
My role |
Funding source |
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2016-2019 |
Co-investigator |
EDCTP HIV/TB diagnostics; a one-stop shop for the same day diagnosis and management of TB and HIV |
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2015-2018 |
Supervisor/ Advisor |
Commonwealth PhD Scholarship/ Epistem Optimizing the Diagnosis and Management of Tuberculosis (TB) and Diabetes Mellitus (DM) among HIV Patients in a high TB and HIV burden setting (student: Rotimi Owolabi) |
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2015-2018 |
Primary Supervisor |
Wellcome Trust Clinical PhD Fellowship awarded to Dr Andrew McCallum |
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2015-2017 |
Principal Investigator |
British Society for Antimicrobial Chemotherapy Effect of MIC distribution on clinical PK-PD modelling to predict treatment outcome in pulmonary TB patients from Blantyre, Malawi |
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2015-2017 |
Principal Investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Drug resistance in TB: Microbiological & pharmacological variability influencing outcomes |
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2015-2017 |
Co-investigator |
Wellcome Trust Institutional Strategic Support Fund Grant to LSTM Rational development of an optimal treatment regimen for isoniazid mono-resistant TB |
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2010-2012 |
Co-investigator & collaborator |
Wellcome Trust Masters Training Fellowship awarded to Mr David Mzinza |
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2008-2012 |
Principal Investigator |
Wellcome Trust Clinical PhD Fellowship |
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2008 |
Principal Investigator |
LSTM Equipment Grant (Awarded to set up a mycobacterial liquid culture facility in BSL3 laboratory) |
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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Medicine, PhD in Infection and Global Health, UNIVERSITY OF LIVERPOOL
1 Sept 2010 → 30 Jun 2013
Award Date: 30 Jun 2013
Master in Science, Postgraduate Certificate in Teaching and Learning in Clinical Practive, University of Chester
1 Sept 2007 → 30 Jun 2008
Award Date: 30 Jun 2008
Diploma in Tropical Medicine and Hygiene (DTM &H), UNIVERSITY OF LIVERPOOL
Award Date: 30 Jun 2004
MRCP (UK), Royal College of Physicians, Glasgow
Award Date: 1 Mar 2003
Bachelor of Medicine, Distinction candidate in Medical Jurisprudence, UNIVERSITY OF GLASGOW
1 Sept 1999 → 30 Jun 2000
Award Date: 30 Jun 2000
Bachelor of Science, Immunology, UNIVERSITY OF GLASGOW
1 Sept 1994 → 30 Jun 1998
Award Date: 30 Jun 1998
External positions
Honorary Senior Lecturer at Liverpool School of Tropical Medicine and Institute of Global Health, UNIVERSITY OF LIVERPOOL
31 Jan 2016 → …
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Bedaquiline: what might the future hold?
Shaw, E. S., Stoker, N. G., Potter, J. L., Claassen, H., Leslie, A., Tweed, C. D., Chiang, C.-Y., Conradie, F., Esmail, H., Lange, C., Pinto, L., Rucsineanu, O., Sloan, D. J., Theron, G., Tisile, P., Voo, T. C., Warren, R. M., Lebina, L. & Lipman, M., 27 Jul 2024, (E-pub ahead of print) In: The Lancet Microbe. In Press, 8 p., 100909.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Bedaquiline-pretomanid-moxifloxacin-pyrazinamide for drug-sensitive and drug-resistant pulmonary tuberculosis treatment: a phase 2c, open-label, multicentre, partially randomised controlled trial
Cevik, M., Thompson, L. C., Upton, C., Rolla, V. C., Malahleha, M., Mmbaga, B., Ngubane, N., Abu Bakar, Z., Rassool, M., Variava, E., Dawson, R., Staples, S., Lalloo, U., Louw, C., Conradie, F., Eristavi, M., Samoilova, A., Skornyakov, S. N., Ntinginya, N. E. & Haraka, F. & 28 others, , 17 May 2024, (E-pub ahead of print) In: The Lancet Infectious Diseases. In Press, 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Evidencing the intersection of environmental, socioeconomic, behavioural and demographic drivers of antibacterial resistance in East Africa
Keenan, K., Papathomas, M., Mshana, S. E., Asiimwe, B., Kiiru, J., Lynch, A. G., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Green, D. L., Jing, W., Olamijuwon, E., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiti, W., Bazira, J. & Sloan, D. J. & 7 others, , 15 Feb 2024, Rochester, NY: SSRN, 26 p.Research output: Working paper › Preprint
Open Access -
Predominance of multidrug-resistant bacteria causing urinary tract infections among symptomatic patients in East Africa: a call for action
Maldonado-Barragán, A., Mshana, S. E., Keenan, K., Ke, X., Gillespie, S. H., Stelling, J., Maina, J., Bazira, J., Muhwezi, I., Mushi, M. F., Green, D. L., Kesby, M., Lynch, A. G., Sabiiti, W., Sloan, D. J., Sandeman, A., Kiiru, J., Asiimwe, B. & Holden, M. T. G., Feb 2024, In: JAC-Antimicrobial Resistance. 6, 1, 11 p., dlae019.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)10 Downloads (Pure) -
Suppression of host gene expression is associated with latent TB infection: a possible diagnostic biomarker
Nakiboneka, R., Margaritella, N., Nyirenda, T., Chaima, D., Walbaum, N., Musisi, E., Tionge, S., Msosa, T., Nliwasa, M., Msefula, C. L., Sloan, D. & Sabiiti, W., 7 Jul 2024, In: Scientific Reports. 14, 11 p., 15621.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure)
Datasets
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Rapid Detection of Bacteraemia and Antimicrobial Susceptibility using a Scattered Light Integrated Collection (SLIC) Device (thesis data)
Falconer, K. (Creator), Gillespie, S. H. (Supervisor) & Sloan, D. J. (Supervisor), University of St Andrews, 4 Jun 2025
DOI: 10.17630/b3a86278-d70d-46b8-9a51-1fbe28eb923e
Dataset: Thesis dataset
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Characterization of DNA methylation in Malawian Mycobacterium tuberculosis clinical isolates (dataset)
Sloan, D. J. (Creator), European Nucleotide Archive (ENA), 2021
https://www.ebi.ac.uk/ena/browser/view/PRJEB28592
Dataset
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Localization and phenotyping of tuberculosis bacteria using a combination of deep learning and SVMs (dataset)
Zachariou, M. (Creator), Arandelovic, O. (Creator), Dombay, E. (Creator), Sabiiti, W. (Creator), Mtafya, B. A. (Creator), Ntinginya, N. (Creator) & Sloan, D. J. (Creator), University of St Andrews, 29 Feb 2024
DOI: 10.17630/a4ccdb1a-53ea-4fb9-9fd2-807bfd2da05d
Dataset
File -
Developing a novel molecular bacterial load assay to improve clinical management of Mycobacterium abscessus infections (thesis data)
Alferes De Lima, D. (Creator), Gillespie, S. H. (Supervisor) & Sloan, D. J. (Supervisor), University of St Andrews, 6 Apr 2022
DOI: 10.17630/e3b3b595-f58e-4b27-88b5-1549db9dc10d
Dataset: Thesis dataset
File -
Towards Fully Automated Analysis of Sputum Smear Microscopy Images (thesis data)
Zachariou, M. (Creator), Arandelovic, O. (Supervisor), Sloan, D. J. (Supervisor), Mtafya, B. A. (Data Collector) & Sabiiti, W. (Data Manager), University of St Andrews, 19 Apr 2024
DOI: 10.17630/28cc5ee6-7cfa-4335-b591-e1e9247dc4f6, https://doi.org/10.17630/sta/858
Dataset: Thesis dataset
File
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Unite4TB H2020: Unite4TB: Academia and industry united innovation and treatment for tuberculosis
Gillespie, S. H. (PI), Sabiiti, W. (CoI) & Sloan, D. J. (CoI)
1/06/21 → 1/05/25
Project: Standard
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Impacting antibiotic dispensing: Impacting antibiotic dispensing in Tanzania: going beyond stricter enforcement of regulations to improved antibiotic stewardship through participatory citizen science
Kesby, M. (PI), Fredricks, K. J. (CoI), Holden, M. (CoI), Keenan, K. L. (CoI), Sabiiti, W. (CoI), Sandeman, A. (CoI) & Sloan, D. J. (CoI)
1/05/22 → 30/04/24
Project: Standard
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CARE: COVID-19 and Antimicrobial Resista: CARE: COVID-19 and Antimicrobial Resistance in East Africa - Impact and Response
Holden, M. (PI), Sabiiti, W. (CoI) & Sloan, D. J. (CoI)
13/11/20 → 12/05/22
Project: Standard
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SFC GCRF Award - July20: Tuberculosis in the time of COVID-19: Improving safety in healthcare facilities
Sloan, D. J. (PI) & Cevik, M. (CoI)
1/08/20 → 31/07/21
Project: Standard
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Prizes
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Conference on Retroviruses & Opportunistic Infections Young Investigator Award
Sloan, D. J. (Recipient), 2013
Prize: Prize (including medals and awards)
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Conference on Retroviruses & Opportunistic Infections Young Investigator Award
Sloan, D. J. (Recipient), 2014
Prize: Prize (including medals and awards)
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European Society for Clinical Microbiology and Infectous Diseases Travel Grant
Sloan, D. J. (Recipient), 2013
Prize: Prize (including medals and awards)
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University of Cape Town Scholarship
Sloan, D. J. (Recipient), 2011
Prize: Prize (including medals and awards)