David Christopher Crossman

2024

Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort

Kirwan, P. D., Hall, V. J., Foulkes, S., Otter, A. D., Munro, K., Sparkes, D., Howells, A., Platt, N., Broad, J., Crossman, D., Norman, C., Corrigan, D., Jackson, C. H., Cole, M., Brown, C. S., Atti, A., Islam, J., SIREN Study Group, Presanis, A. M. & Charlett, A. & 2 others, De Angelis, D. & Hopkins, S., Jan 2024, In: The Lancet Regional Health - Europe. 36, 12 p., 100809.

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2022

Effect of transcatheter aortic valve implantation vs surgical aortic valve replacement on all-cause mortality in patients with aortic stenosis: a randomized clinical trial

UK TAVI Trial Investigators, 17 May 2022, In: JAMA - Journal of the American Medical Association. 327, 19, p. 1875-1887 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension

Arnold, N. D., Pickworth, J. A., West, L. E., Dawson, S., Carvalho, J. A., Casbolt, H., Braithwaite, A. T., Iremonger, J., Renshall, L., Germaschewski, V., McCourt, M., Bland-Ward, P., Kowash, H., Hameed, A. G., Rothman, A. M. K., Frid, M. G., Roger Thompson, A. A., Evans, H. R., Southwood, M. & Morrell, N. W. & 7 others, Crossman, D. C., Whyte, M. K. B., Stenmark, K. R., Newman, C. M., Kiely, D. G., Francis, S. E. & Lawrie, A., 15 Nov 2019, In: Nature Communications. 10, 18 p., 5183.

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Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial

Mullen, M., Jin, X. Y., Child, A., Stuart, A. G., Dodd, M., Aragon-Martin, J. A., Gaze, D., Kiotsekoglou, A., Yuan, L., Hu, J., Foley, C., Van Dyck, L., Knight, R., Clayton, T., Swan, L., Thomson, J. D. R., Erdem, G., Crossman, D., Flather, M. & AIMS Investigators, 21 Dec 2019, In: Lancet. 394, 10216, p. 2263-2270

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2018

ATP evokes Ca²⁺ responses and CXCL5 secretion via P2X₄ receptor activation in human monocyte-derived macrophages

Layhadi, J. A., Turner, J., Crossman, D. & Fountain, S. J., 1 Feb 2018, In: The Journal of Immunology. 200, 3, p. 1159-1168

Research output: Contribution to journal › Article › peer-review

Open Access

Canakinumab for atherosclerotic disease

MRC-ILA Heart investigators, Rothman, A. M., Morton, A. C. & Crossman, D. C., 11 Jan 2018, In: New England Journal of Medicine. 378, 2, p. 197-8 2 p.

Research output: Contribution to journal › Article › peer-review

Dietary docosahexaenoic acid reduces oscillatory wall shear stress, atherosclerosis and hypertension, most likely mediated via an IL-1-mediated mechanism

Alfaida, M., Chamberlain, J., Rothman, A., Crossman, D. C., Villa-Uriol, M.-C., Hadoke, P., Wu, J., Schenkel, T., Evans, P. & Francis, S., 3 Jul 2018, In: Journal of the American Heart Association. 7, 13, 19 p., e008757.

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis

Freitag, D., Butterworth, A. S., Willeit, P., Howson, J. M. M., Burgess, S., Kaptoge, S., Young, R., Ho, W. K., Wood, A. M., Sweeting, M., Spackman, S., Staley, J. R., Ramond, A., Harshfield, E., Nielsen, S. F., Grande, P., Lange, L. A., Bown, M. J., Jones, G. T. & Scott, R. A. & 133 others, Bevan, S., Porcu, E., Thorleifsson, G., Zeng, L., Kessler, T., Nikpay, M., Do, R., Zhang, W., Hopewell, J. C., Kleber, M., Delgado, G. E., Nelson, C. P., Goel, A., Bis, J. C., Dehghan, A., Ligthart, S., Smith, A. V., Qu, L., van 't Hof, F. N. G., de Bakker, P. I. W., Baas, A. F., van Rij, A., Tromp, G., Kuivaniemi, H., Ritchie, M. D., Verma, S. S., Crawford, D. C., Malinowski, J., de Andrade, M., Kullo, I. J., Peissig, P. L., McCarty, C. A., Böttinger, E. P., Gottesman, O., Crosslin, D. R., Carrell, D. S., Rasmussen-Torvik, L. J., Pacheco, J. A., Huang, J., Timpson, N. J., Kettunen, J., Ala-Korpela, M., Mitchell, G. F., Parsa, A., Wilkinson, I. B., Gorski, M., Li, Y., Franceschini, N., Keller, M. F., Ganesh, S. K., Langefeld, C. D., Bruijn, L., Brown, M. A., Evans, D. M., Baltic, S., Ferreira, M. A., Baurecht, H., Weidinger, S., Franke, A., Lubitz, S. A., Müller-Nurasyid, M., Felix, J. F., Smith, N. L., Sudman, M., Thompson, S. D., Zeggini, E., Panoutsopoulou, K., Nalls, M. A., Singleton, A., Polychronakos, C., Bradfield, J. P., Hakonarson, H., Easton, D. F., Thompson, D., Tomlinson, I. P., Dunlop, M., Hemminki, K., Morgan, G., Eisen, T., Goldschmidt, H., Allan, J. M., Henrion, M., Whiffin, N., Wang, Y., Chubb, D., Iles, M. M., Bishop, D. T., Law, M. H., Hayward, N. K., Luo, Y., Nejentsev, S., Barbalic, M., Crossman, D., Sanna, S., Soranzo, N., Markus, H. S., Wareham, N. J., Rader, D. J., Reilly, M., Assimes, T., Harris, T. B., Hofman, A., Franco, O. H., Gudnason, V., Tracy, R., Psaty, B. M., Farrall, M., Watkins, H., Hall, A. S., Samani, N. J., März, W., Clarke, R., Collins, R., Kooner, J. S., Chambers, J. C., Kathiresan, S., McPherson, R., Erdmann, J., Kastrati, A., Schunkert, H., Stefánsson, K., Thorsteinsdottir, U., Walston, J. D., Tybjærg-Hansen, A., Alam, D. S., Al Shafi Majumder, A., Angelantonio, E. D., Chowdhury, R., Nordestgaard, B. G., Saleheen, D., Thompson, S. G., Danesh, J. & Houlston, R. S., 1 Apr 2015, In: The Lancet Diabetes & Endocrinology. 3, 4, p. 243-253 11 p.

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The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study

Morton, A. C., Rothman, A. M. K., Greenwood, J. P., Gunn, J., Chase, A., Clarke, B., Hall, A. S., Fox, K., Foley, C., Banya, W., Wang, D., Flather, M. D. & Crossman, D. C., 7 Feb 2015, In: European Heart Journal. 36, 6, p. 377-384 8 p.

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Open Access

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2014

P2Y(6) receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells

Campwala, H., Sexton, D. W., Crossman, D. C. & Fountain, S. J., 15 Nov 2014, In: Journal of Cell Science. 127, 22, p. 4964-4973 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2013

Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling

Watson, O., Novodvorsky, P., Gray, C., Rothman, A. M. K., Lawrie, A., Crossman, D. C., Haase, A., McMahon, K., Gering, M., Van Eeden, F. J. M. & Chico, T. J. A., 1 Nov 2013, In: Cardiovascular Research. 100, 2, p. 252-261 10 p.

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Open Access

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2012

Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5

Nolan, D. K., Sutton, B., Haynes, C., Johnson, J., Sebek, J., Dowdy, E., Crosslin, D., Crossman, D., Sketch, M. H., Granger, C. B., Seo, D., Goldschmidt-Clermont, P., Kraus, W. E., Gregory, S. G., Hauser, E. R. & Shah, S. H., 27 Feb 2012, In: BMC Genetics. 13, 12.

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David Christopher Crossman

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