Research output per year
Research output per year
Personal profile
Profile Keywords
Statistics; Cancer; Genomics; Computational Biology
Biography
Professor Lynch joined the University of St Andrews in 2017 after 15 years at the University of Cambridge working in the Department of Public Health and Primary Care, The Department of Oncology and for the most part the Cancer Research UK Cambridge Institute. Divided between the Schools of Medicine, and Mathematics and Statistics, in St Andrews his research is divided between the development and application of analysis methods - typically in the context of cancer genomics.
Research overview
Professor Lynch works on the development and application of analysis methods for cancer sequencing data. This includes questions of experimental design within cancer genomics, fundamental questions regarding the extraction of data (and uncertainty) from modern biological methods, methods for answering biological and clinical questions in new ways, and applications to multiple cancer types (including Prostate, Glioblastoma, Oesophageal, Breast, Renal, Ovarian and Lung).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Evidencing the intersection of environmental, socioeconomic, behavioural and demographic drivers of antibacterial resistance in East Africa
Keenan, K., Papathomas, M., Mshana, S. E., Asiimwe, B., Kiiru, J., Lynch, A. G., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Green, D. L., Jing, W., Olamijuwon, E., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiti, W., Bazira, J. & Sloan, D. J. & 7 others, , 15 Feb 2024, Rochester, NY: SSRN, 26 p.Research output: Working paper › Preprint
Open Access -
Genomic evolution shapes prostate cancer disease type
CRUK-ICGC Prostate Group, Woodcock, D. J., Sahli, A., Teslo, R., Bhandari, V., Gruber, A. J., Ziubroniewicz, A., Gundem, G., Xu, Y., Butler, A., Anokian, E., Pope, B. J., Jung, C.-H., Tarabichi, M., Dentro, S. C., Farmery, J. H. R., Van Loo, P., Warren, A. Y., Gnanapragasam, V. & Hamdy, F. C. & 16 others, , 13 Mar 2024, (E-pub ahead of print) In: Cell Genomics. 4, 13, 31 p., 100511.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use
Keenan, K. L., Papathomas, M., Mshana, S., Asiimwe, B., Kiiru, J., Lynch, A., Kesby, M., Neema, S., Mwanga, J. R., Mushi, M. F., Jing, W., Green, D. L., Olamijuwon, E. O., Zhang, Q., Sippy, R., Fredricks, K. J., Gillespie, S. H., Sabiiti, W., Bazira, J. & Sloan, D. J. & 8 others, , 31 Oct 2024, In: Nature Communications. 15, 11 p., 9418.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Predominance of multidrug-resistant bacteria causing urinary tract infections among symptomatic patients in East Africa: a call for action
Maldonado-Barragán, A., Mshana, S. E., Keenan, K., Ke, X., Gillespie, S. H., Stelling, J., Maina, J., Bazira, J., Muhwezi, I., Mushi, M. F., Green, D. L., Kesby, M., Lynch, A. G., Sabiiti, W., Sloan, D. J., Sandeman, A., Kiiru, J., Asiimwe, B. & Holden, M. T. G., Feb 2024, In: JAC-Antimicrobial Resistance. 6, 1, 11 p., dlae019.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Prostate cancer detection through unbiased capture of methylated cell-free DNA
Lleshi, E., Milne-Clark, T., Lee Yu, H., Martin, H. W., Hanson, R., Lach, R., Rossi, S. H., Riediger, A. L., Görtz, M., Sültmann, H., Flewitt, A., Lynch, A. G., Gnanapragasam, V. J., Massie, C. E. & Dev, H. S., 20 Jun 2024, (E-pub ahead of print) In: iScience. 27, 7, 17 p., 110330.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Mutational signatures of ionizing radiation in second malignancies (dataset)
Lynch, A. (Creator), European Genome-phenome Archive (EGA), 2016
https://www.ebi.ac.uk/ega/studies/EGAS00001000138 and 2 more links, https://www.ebi.ac.uk/ega/studies/EGAS00001000147, https://www.ebi.ac.uk/ega/search/site/EGAS00001000195 (show fewer)
Dataset
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Additional files 1, 3-8 of The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates
Buhigas, C. (Creator), Warren, A. Y. (Creator), Leung, W.-K. (Creator), Whitaker, H. C. (Creator), Luxton, H. J. (Creator), Hawkins, S. (Creator), Kay, J. (Creator), Butler, A. (Creator), Xu, Y. (Creator), Woodcock, D. J. (Creator), Merson, S. (Creator), Frame, F. M. (Creator), Sahli, A. (Creator), Abascal, F. (Creator), Martincorena, I. (Creator), Bova, G. S. (Creator), Foster, C. S. (Creator), Campbell, P. (Creator), Maitland, N. J. (Creator), Neal, D. E. (Creator), Massie, C. E. (Creator), Lynch, A. G. (Creator), Eeles, R. A. (Creator), Cooper, C. S. (Creator), Wedge, D. C. (Creator) & Brewer, D. S. (Creator), Figshare, 2022
DOI: 10.6084/m9.figshare.21185567.v1, https://doi.org/10.6084/m9.figshare.21185573.v1 and 5 more links, https://doi.org/10.6084/m9.figshare.21185576.v1, https://doi.org/10.6084/m9.figshare.21185579.v1, https://doi.org/10.6084/m9.figshare.21185588.v1, https://doi.org/10.6084/m9.figshare.21185591.v1, https://doi.org/10.6084/m9.figshare.21185594.v1 (show fewer)
Dataset
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Tool to estimate glomerular filtration
Janowitz, T. (Creator), Williams, E. H. (Creator), Marshall, A. (Creator), Ainsworth, N. (Creator), Thomas, P. B. (Creator), Sammut, S. J. (Creator), Shepherd, S. (Creator), White, J. (Creator), Mark, P. B. (Creator), Lynch, A. (Creator), Jodrell, D. I. (Creator), Tavaré, S. (Creator) & Earl, H. (Creator), University of Cambridge, 2017
https://sites.google.com/site/janowitzwilliamsgfr/
Dataset
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Cholinekinase alpha as an androgen receptor chaperone and prostate cancer therapeutic target (dataset)
Lynch, A. (Creator), Gene Expression Omnibus (GEO), 2015
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi
Dataset
Projects
- 5 Finished
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Who bears the burden of antibiotic resistance in East Africa? Mathematical modelling of socioeconomic disadvantage and resistance
Sippy, R. (PI), Keenan, K. L. (CoI), Lynch, A. (CoI), Holden, M. (CoI), Kesby, M. (CoI) & Smith, V. A. (CoI)
STAIRS - St Andrews Interdisciplinary Research Support
1/09/22 → 31/07/23
Project: Standard
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Seleno-proteins in prostate cancer risk: Profiling seleno-proteins in prostate cancer to understand risk
Lynch, A. (PI)
1/11/20 → 31/07/21
Project: Standard
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Prof M Holden MRC: Holistic approach to unravel antibacterial resistance in East Africa (HATUA)
Holden, M. (PI), Gillespie, S. H. (CoI), Keenan, K. L. (CoI), Kesby, M. (CoI), Lynch, A. (CoI), Sabiiti, W. (CoI), Sloan, D. J. (CoI) & Smith, V. A. (CoI)
1/05/18 → 30/04/21
Project: Standard
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Prof M Holden - MRC: Holistic Approach Towards Unravelling Antibiotic Resistance in East Africa
Holden, M. (PI), Gillespie, S. H. (CoI), Kesby, M. (CoI), Lynch, A. (CoI), Sabiiti, W. (CoI), Sloan, D. J. (CoI) & Thomas, L. (CoI)
1/11/17 → 30/06/18
Project: Standard
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CRUK Prostate International Cancer: CRUK Prostate International Cancer Genome Consortium Project
Lynch, A. (PI)
12/06/17 → 31/05/19
Project: Standard
Prizes
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3-year studentship by The Melville Trust for the Care and Cure of Cancer
Papathomas, M. (Recipient) & Lynch, A. (Recipient), 3 Jul 2019
Prize: Prize (including medals and awards)