Personal profile
Profile Keywords
- Bacterial pathogenesis
- Bacterial evolution
- Mobile genetic elements and interactions
- Bacteriophages
- Phage lifecycle regulation
- Pathogenicity islands
- Antimicrobial resistance
- Antimicrobial therapy
Research overview
Bacterial infections and the rise of antimicrobial resistance (AMR) are a significant global threat already involved in almost 5 million deaths annually. Many bacterial pathogens harbour multiple mobile genetic elements (MGEs), which play a crucial role in their ability to cause disease. Many MGEs are known to interact with each other yet how more complex MGE interactions affect a pathogen’s success has not yet been determined. My research group tackles this challenge by investigating how interactions between MGEs in bacteria, particularly Staphylococcus aureus, influence their evolution, virulence, and ability to resist antibiotics, ultimately driving their success.
Our mission is to understand how MGEs collaborate and compete to shape bacterial pathogens, ultimately aiming to develop new strategies to combat infections.
We achieve this mission by:
- Characterising the molecular mechanisms underlying key MGE interactions.
- Defining the impact of MGE interactions on bacterial evolution and antibiotic resistance.
- Investigating how MGE interactions influence bacterial virulence and pathogenicity.
- Utilising our findings to develop novel treatment strategies against bacterial infections.
Education/Academic qualification
Doctor of Philosophy, Microbiology, University of Aberdeen
1 Oct 2007 → 25 Nov 2011
Award Date: 25 Nov 2011
Dipl.-Ing. (FH) Biotechnology, Weihenstephan-Triesdorf University of Applied Sciences
1 Oct 2002 → 8 May 2007
Award Date: 8 May 2007
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 15 Life on Land
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Draft genome sequence of a non-tuberculous Mycobacterium strain isolated from a clinical urine sample
Rivas Ramos, J. E., Johnston, P. R., Hammond, R. J. H., Holden, M. T. G., Sloan, D. J. & Haag, A. F., 28 Jan 2026, In: Access Microbiology. 8, 1, p. 1-4 4 p., 001110.v3.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Podkowik, M., Perault, A. I., Putzel, G., Pountain, A., Kim, J., DuMont, A. L., Zwack, E. E., Ulrich, R. J., Karagounis, T. K., Zhou, C., Haag, A. F., Shenderovich, J., Wasserman, G. A., Kwon, J., Chen, J., Richardson, A. R., Weiser, J. N., Nowosad, C. R., Lun, D. S. & Parker, D. & 6 others, , 30 Apr 2024, In: eLife. 12, 32 p., RP89098.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
In vivo gene expression profiling of Staphylococcus aureus during infection informs design of stemless leukocidins LukE and -D as detoxified vaccine candidates
Haag, A., Liljeroos, L., Donato, P., Pozzi, C., Brignoli, T., Bottomley, M. J., Bagnoli, F. & Delany, I., 1 Feb 2023, In: Microbiology Spectrum. 11, 1, 19 p., e02574-22.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Podkowik, M., Perault, A. I., Putzel, G., Pountain, A., Kim, J., DuMont, A., Zwack, E., Ulrich, R. J., Karagounis, T. K., Zhou, C., Haag, A. F., Shenderovich, J., Wasserman, G. A., Kwon, J., Chen, J., Richardson, A. R., Weiser, J. N., Nowosad, C. R., Lun, D. S. & Zhao, X. & 7 others, , 8 Jun 2023, bioRxiv, 64 p.Research output: Working paper › Preprint
Open Access -
S. aureus antigens and compositions thereof
Bagnoli, F., Haag, A. & Liljeroos, L., 1 Feb 2023, Google Patents.Research output: Other contribution
Datasets
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Draft genome sequence of a non-tuberculous Mycobacterium strain isolated from a clinical urine sample (dataset0
Johnston, P. (Creator), Hammond, R. (Creator), Sloan, D. (Creator) & Haag, A. (Creator), NCBI GenBank, 2025
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1229527/
Dataset
Projects
- 2 Finished
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Dr Andreas Haag - Round 8 Funding: Dr Andreas haag - ISSF Funding Round 8
Haag, A. (PI)
1/08/22 → 31/03/23
Project: Standard
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The ClpX protease is essential for inactivating the CI master repressor and completing prophage induction in Staphylococcus aureus
Haag, A. (Speaker)
10 Apr 2024Activity: Talk or presentation types › Presentation
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Antimicrobial resistance: a threat to modern society
Haag, A. (Speaker)
30 Nov 2023Activity: Talk or presentation types › Invited talk
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Unravelling the final stage of prophage induction in Staphylococcus aureus
Haag, A. (Speaker)
8 Sept 2023Activity: Talk or presentation types › Presentation
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Unravelling the final stage of prophage induction in Staphylococcus aureus
Haag, A. (Speaker)
27 Jan 2023Activity: Talk or presentation types › Presentation