Research output per year
Research output per year
Personal profile
Profile Keywords
- Bacterial pathogenesis
- Bacterial evolution
- Mobile genetic elements and interactions
- Bacteriophages
- Phage lifecycle regulation
- Pathogenicity islands
- Antimicrobial resistance
- Antimicrobial therapy
Research overview
Bacterial infections and the rise of antimicrobial resistance (AMR) are a significant global threat already involved in almost 5 million deaths annually. Many bacterial pathogens harbour multiple mobile genetic elements (MGEs), which play a crucial role in their ability to cause disease. Many MGEs are known to interact with each other yet how more complex MGE interactions affect a pathogen’s success has not yet been determined. My research group tackles this challenge by investigating how interactions between MGEs in bacteria, particularly Staphylococcus aureus, influence their evolution, virulence, and ability to resist antibiotics, ultimately driving their success.
Our mission is to understand how MGEs collaborate and compete to shape bacterial pathogens, ultimately aiming to develop new strategies to combat infections.
We achieve this mission by:
- Characterising the molecular mechanisms underlying key MGE interactions.
- Defining the impact of MGE interactions on bacterial evolution and antibiotic resistance.
- Investigating how MGE interactions influence bacterial virulence and pathogenicity.
- Utilising our findings to develop novel treatment strategies against bacterial infections.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Microbiology, University of Aberdeen
1 Oct 2007 → 25 Nov 2011
Award Date: 25 Nov 2011
Dipl.-Ing. (FH) Biotechnology, Weihenstephan-Triesdorf University of Applied Sciences
1 Oct 2002 → 8 May 2007
Award Date: 8 May 2007
Fingerprint
Dive into the research topics where Andreas Haag is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
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In vivo gene expression profiling of Staphylococcus aureus during infection informs design of stemless leukocidins LukE and -D as detoxified vaccine candidates
Haag, A., Liljeroos, L., Donato, P., Pozzi, C., Brignoli, T., Bottomley, M. J., Bagnoli, F. & Delany, I., 1 Feb 2023, In: Microbiology Spectrum. 11, 1, 19 p., e02574-22.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Downloads (Pure) -
Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Shopsin, B., Podkowik, M., Perault, A. I., Putzel, G., Pountain, A., Kim, J., DuMont, A., Zwack, E., Ulrich, R. J., Karagounis, T. K., Zhou, C., Haag, A. F., Shenderovich, J., Wasserman, G. A., Kwon, J., Chen, J., Richardson, A. R., Weiser, J. N., Nowosad, C. R. & Lun, D. S. & 6 others, , 8 Jun 2023, bioRxiv, (biorxiv).Research output: Working paper › Preprint
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Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress
Podkowik, M., Perault, A. I., Putzel, G., Pountain, A., Kim, J., Dumont, A., Zwack, E., Ulrich, R. J., Karagounis, T. K., Zhou, C., Haag, A. F., Shenderovich, J., Wasserman, G. A., Kwon, J., Chen, J., Richardson, A. R., Weiser, J. N., Nowosad, C. R., Lun, D. S. & Parker, D. & 6 others, , 26 Jul 2023, eLife Sciences Publications, Ltd.Research output: Other contribution
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S. aureus antigens and compositions thereof
Bagnoli, F., Haag, A. & Liljeroos, L., 1 Feb 2023, Google Patents.Research output: Other contribution
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The ClpX protease is essential for inactivating the CI master repressor and completing prophage induction in Staphylococcus aureus
Thabet, M. A., Penades, J. R. & Haag, A., 18 Oct 2023, In: Nature Communications. 14, 16 p., 6599.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)15 Downloads (Pure)
Datasets
Projects
- 2 Finished
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Dr Andreas Haag - Round 8 Funding: Dr Andreas haag - ISSF Funding Round 8
Haag, A. (PI)
1/08/22 → 31/03/23
Project: Standard
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The ClpX protease is essential for inactivating the CI master repressor and completing prophage induction in Staphylococcus aureus
Haag, A. (Speaker)
10 Apr 2024Activity: Talk or presentation types › Presentation
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Antimicrobial resistance: a threat to modern society
Haag, A. (Speaker)
30 Nov 2023Activity: Talk or presentation types › Invited talk
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Unravelling the final stage of prophage induction in Staphylococcus aureus
Haag, A. (Speaker)
8 Sept 2023Activity: Talk or presentation types › Presentation
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Unravelling the final stage of prophage induction in Staphylococcus aureus
Haag, A. (Speaker)
27 Jan 2023Activity: Talk or presentation types › Presentation