Ultra-sensitive detection of circulating tumour DNA enriches for patients with greater risk of recurrence in clinically localised prostate cancer (dataset)

  • Bernard Pope (Creator)
  • Gahee Park (Creator)
  • Edmund Lau (Creator)
  • Jelena Belic (Creator)
  • Radoslaw Lach (Creator)
  • Anne George (Creator)
  • Patrick McCoy (Creator)
  • Anne Nguyen (Creator)
  • Corrina Grima (Creator)
  • Bethany Campbell (Creator)
  • Chol-hee Jung (Creator)
  • Emma-Jane Ditter (Creator)
  • Hui Zhao (Creator)
  • David Wedge (Creator)
  • Daniel Brewer (Creator)
  • Andy Lynch (Creator)
  • Harveer Dev (Creator)
  • Vincent Gnanpragasam (Creator)
  • Nitzan Rosenfeld (Creator)
  • Christopher Hovens (Creator)
  • Niall Corcoran (Creator)
  • Charlie Massie (Creator)
  • CR-UK/Prostate Cancer UK, ICGC, The PPCG (Creator)

Dataset

Description

These files comprise the supplementary data for Pope et al. (2024) "Ultra-sensitive detection of circulating tumour DNA enriches for patients with greater risk of recurrence in clinically localised prostate cancer"

Supplementary Table 1 (in 1-s2.0-S0302283824000034-mmc1.docx) describes the clinical characteristics of the participants in the paper, combining 41 samples from Australia and 77 samples from the UK.

Supplementary Table 2 (in 1-s2.0-S0302283824000034-mmc2.xlsx) describes the 128 healthy male controls used in the paper, and the analysis batches for which they were used.

Supplementary Table 3 (in 1-s2.0-S0302283824000034-mmc1.docx) describes the 17 analysis batches studied in the paper.

Supplementary Table 4 (in 1-s2.0-S0302283824000034-mmc3.xlsx) details the key sequencing statistics, including the number of targets (by batch and by patient), the sequencing coverage achieved, and the proportion of targets covered for different thresholds.

Supplementary Table 5 (in 1-s2.0-S0302283824000034-mmc4.xlsx) details for 118 patients their key demographic, clinical and molecular characteristics, as well as whether circulating tumour DNA was detected.

Supplementary Table 6 (1-s2.0-S0302283824000034-mmc5.docx) Further details of cases where circulating tumour DNA was detected

Supplementary Table 7 (in 1-s2.0-S0302283824000034-mmc1.docx) Gives the outcome of an analysis of time to biochemical recurrence modelled in terms of PSA, pathologist T stage, ISUP grade group and whether ctDNA was detected.

Supplementary Table 8 (in 1-s2.0-S0302283824000034-mmc1.docx) Gives the outcome of an analysis of time to metastasis modelled in terms of PSA, pathologist T stage, ISUP grade group and whether ctDNA was detected.

Supplementary Table 9 (in 1-s2.0-S0302283824000034-mmc1.docx) Gives a summary of all survival models (both outcomes and whether adjusted for covariates or not).

Supplementary Table X (1-s2.0-S0302283824000034-mmc6.xlsx) Details of the members of the author collaboration "The Pan Prostate Cancer Group (PPCG)"
Date made available13 Jan 2025
PublisherUniversity of St Andrews

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