Research output per year
Research output per year
Description
Temporal genome dynamics of ST39 Klebsiella pneumoniae in a neonatal unit in Blantyre, Malawi
In this study, we investigated the genomic changes that occurred during long-term circulation of a Klebsiella pneumoniae ST39 clone, causing a disproportionate number of infections on the neonatal ward at a tertiary healthcare facility in Malawi in 2017. We analysed whole genome sequences of Klebsiella pneumoniae ST39 collected from Queen Elizabeth Central Hospital over a 20-year period, including generation of several high-quality hybrid genomes. We compared virulence markers, antibiotic resistance determinants, and mobile genetic elements, focusing on variable regions between strains from the outbreak clone in 2017 to genomes from other co-occurring ST39 lineages.
In this study, we investigated the genomic changes that occurred during long-term circulation of a Klebsiella pneumoniae ST39 clone, causing a disproportionate number of infections on the neonatal ward at a tertiary healthcare facility in Malawi in 2017. We analysed whole genome sequences of Klebsiella pneumoniae ST39 collected from Queen Elizabeth Central Hospital over a 20-year period, including generation of several high-quality hybrid genomes. We compared virulence markers, antibiotic resistance determinants, and mobile genetic elements, focusing on variable regions between strains from the outbreak clone in 2017 to genomes from other co-occurring ST39 lineages.
| Date made available | 2026 |
|---|---|
| Publisher | NCBI GenBank |
Research output
- 1 Article
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Temporal genomic dynamics of sequence type 39 Klebsiella pneumoniae in a neonatal unit in Blantyre, Malawi
Zuza, A. M., Pearse, O., Domman, D. B., Dyson, Z. A., Kawaza, K., Musicha, P., Feasey, N. A. & Heinz, E., 1 Apr 2026, In: Microbial Genomics. 12, 4, p. 1-12 12 p., 001673.Research output: Contribution to journal › Article › peer-review
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