Human Dihydroorotate Dehydrogenase in complex with novel inhibitor (PDB entry 6ET4)

  • Marcus J.G.W. Ladds (Creator)
  • Ingeborg M.M. van Leeuwen (Creator)
  • Catherine J. Drummond (Creator)
  • Su Chu (Creator)
  • Alan Healy (Creator)
  • Gergana Popova (Creator)
  • Andrés Pastor-Fernández (Creator)
  • Tanzina Mollick (Creator)
  • Suhas Darekar (Creator)
  • Saikiran K. Sedimbi (Creator)
  • Marta Nekulova (Creator)
  • Marijke C.C. Sachweh (Creator)
  • Johanna Campbell (Creator)
  • Maureen Higgins (Creator)
  • Chloe Tuck (Creator)
  • Mihaela Popa (Creator)
  • Mireia Mayoral Safont (Creator)
  • Pascal Gelebart (Creator)
  • Zinayida Fandalyuk (Creator)
  • Alastair M. Thompson (Creator)
  • Richard Svensson (Creator)
  • Anna-Lena Gustavsson (Creator)
  • Lars Johansson (Creator)
  • Katarina Färnegårdh (Creator)
  • Ulrika Yngve (Creator)
  • Aljona Saleh (Creator)
  • Martin Haraldsson (Creator)
  • Agathe Clotilde Aline D'Hollander (Creator)
  • Marcela Franco (Creator)
  • Yan Zhao (Creator)
  • Maria Håkansson (Creator)
  • Björn Walse (Creator)
  • Karin Larsson (Creator)
  • Emma M. Peat (Creator)
  • Vicent Pelechano (Creator)
  • John Lunec (Creator)
  • Borivoj Vojtesek (Creator)
  • Mar Carmena (Creator)
  • William C. Earnshaw (Creator)
  • Nicholas James Westwood (Creator)
  • Marie Arsenian Henriksson (Creator)
  • David P. Lane (Creator)
  • Ravi Bhatia (Creator)
  • Emmet McCormack (Creator)
  • Sonia Laín (Creator)

Dataset

Description

atomic coordinates and structure factors
Date made available28 Mar 2018
PublisherProtein Data Bank (PDB)

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  • A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

    Ladds, M. J. G. W., van Leeuwen, I. M. M., Drummond, C. J., Chu, S., Healy, A. R., Popova, G., Pastor-Fernández, A., Mollick, T., Darekar, S., Sedimbi, S. K., Nekulova, M., Sachweh, M. C. C., Campbell, J., Higgins, M., Tuck, C., Popa, M., Safont, M. M., Gelebart, P., Fandalyuk, Z. & Thompson, A. M. & 26 others, Svensson, R., Gustavsson, A.-L., Johansson, L., Färnegårdh, K., Yngve, U., Saleh, A., Haraldsson, M., D'Hollander, A. C. A., Franco, M., Zhao, Y., Håkansson, M., Walse, B., Larsson, K., Peat, E. M., Pelechano, V., Lunec, J., Vojtesek, B., Carmena, M., Earnshaw, W. C., McCarthy, A. R., Westwood, N. J., Arsenian-Henriksson, M., Lane, D. P., Bhatia, R., McCormack, E. & Laín, S., 16 Mar 2018, In: Nature Communications. 9, 1107.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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