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Evolutionary transcriptomic and cellular specializations within the mammalian striatum

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Description

In this study we generated and analyzed single-nucleus RNA sequencing (snRNA-seq) of human, chimpanzee, rhesus macaque (this study and GSE167920), marmoset (GSE151761 and GSE165578), bat caudate (CN) and putamen (Pu) separately, ferret caudate (GSE151761), and mouse caudoputamen (C-Pu)(GSE151761) spanning 94 million years of evolution. We identified novel interneuron cell types in bat Pu while uncovering fundamental cellular compositional and transcriptomic differences between primate and non-primate striata.
Date made available27 Mar 2026
PublisherNCBI GenBank

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  • Comparative analysis of the cellular landscape in mammalian striatum

    Buyukkahraman, G., Caglayan, E., Hörpel, S. G., Zhang, Y., van Tussenbroek, I. A., Orozco, C. G., Oh, E., Hopkins, W. D., Sherwood, C. C., Roberts, T. F., Vernes, S. C. & Konopka, G., 21 Jul 2026, In: Nature Communications. 17, p. 1-15 15 p., 6793.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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