Researchers at the University of St Andrews say a greater understanding of how zinc is handled in our body could lead to improved treatments for people with diabetes.

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The team of scientists, funded by us, have been investigating the causes of potentially dangerous blood clots and why these more commonly occur in people with diabetes.

Diabetes is a major risk factor for heart and circulatory diseases. Because of the damage it causes to the blood vessels, people with diabetes are up to three times more likely to develop conditions like heart attacks, stroke and vascular dementia. 

Dangerous blood clots

Researchers at the university, led by Dr Alan Stewart, have been looking at the role of zinc in these processes. Zinc is an essential nutrient that serves many functions in the body. One of its functions is to help the blood clot after injury. However in some people with underlying health conditions, such as those with type 2 diabetes or obesity, clotting can occur more often when it’s not required, causing damage to blood vessels and lead to serious health conditions such as stroke and deep vein thrombosis (DVT).

The St Andrews team found the transportation of zinc in the blood is compromised in those with type 2 diabetes due to the increased levels of fatty acids. These fatty acids prevent zinc being carried in the normal way allowing zinc to interact with clot-activating proteins and potentially triggering dangerous blood clots.

Although further research is needed, they believe their study identifies a new way that vascular problems can occur in certain individuals.

Improving treatments 

Dr Stewart, a Senior Lecturer and Principal Investigator at University of St Andrews, says: “Our research suggests that by altering how zinc is handled, elevated levels of fatty acids in the circulation can contribute to the formation of unwanted and potentially dangerous blood clots.

”Ultimately, we hope that these findings will aid the development of new therapeutic strategies to reduce vascular disease risk in patients with type 2 diabetes, as well as other diseases associated with high levels of circulatory fatty acids”.

The findings have now been published in the scientific journal, Chemical Science. 

Our Head of BHF Scotland, James Jopling, adds: “Diabetes is a major risk factor for heart attacks and strokes - conditions which can severely affect quality of life. As such, it is vital we understand more about it and how to treat it. Research projects like this one in St Andrews help inform how we treat patients, identify those at particular risk and ultimately find new ways to save and improve lives.”

Period1 Mar 2021

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