SARS-CoV-2 envelope structural protein found to form voltage-activated and calcium-activated calcium channels

Press/Media: Relating to Research

Period14 Oct 2022

Media coverage

1

Media coverage

  • TitleSARS-CoV-2 envelope structural protein found to form voltage-activated and calcium-activated calcium channels
    Media name/outletnews-medical.net
    Media typeWeb
    Duration/Length/SizeShort summary article
    Country/TerritoryUnited Kingdom
    Date14/10/22
    DescriptionIn a recent study posted to the bioRxiv* preprint server, researchers investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein activity in terms of calcium cations (Ca2+) cations.

    Functional ion channels are critical in the infectious cycles of several viruses since viruses modify host ionic balance (especially Ca2+) to facilitate their uptake, maturation, and export. Viroporins encoded in viral genomes are essential for altering ionic and cellular homeostasis. SARS-CoV-2 E forms ion channels in the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) membranes in association with SARS-CoV-2 virulence and progression of infection.

    Studies have reported that blockade, deletion, or loss-of-function mutations in CoV E proteins can generate attenuated or propagation-lacking viral variants; however, precise physiological functions of SARS-CoV-2 E are not well-characterized and require further investigations.
    Producer/AuthorPooja Toshniwal Paharia
    URLhttps://www.news-medical.net/news/20221014/SARS-CoV-2-envelope-structural-protein-found-to-form-voltage-activated-and-calcium-activated-calcium-channels.aspx
    PersonsQuenton Hurst