Media coverage
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Media coverage
Title SARS-CoV-2 envelope structural protein found to form voltage-activated and calcium-activated calcium channels Media name/outlet news-medical.net Media type Web Duration/Length/Size Short summary article Country/Territory United Kingdom Date 14/10/22 Description In a recent study posted to the bioRxiv* preprint server, researchers investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein activity in terms of calcium cations (Ca2+) cations.
Functional ion channels are critical in the infectious cycles of several viruses since viruses modify host ionic balance (especially Ca2+) to facilitate their uptake, maturation, and export. Viroporins encoded in viral genomes are essential for altering ionic and cellular homeostasis. SARS-CoV-2 E forms ion channels in the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) membranes in association with SARS-CoV-2 virulence and progression of infection.
Studies have reported that blockade, deletion, or loss-of-function mutations in CoV E proteins can generate attenuated or propagation-lacking viral variants; however, precise physiological functions of SARS-CoV-2 E are not well-characterized and require further investigations.Producer/Author Pooja Toshniwal Paharia URL https://www.news-medical.net/news/20221014/SARS-CoV-2-envelope-structural-protein-found-to-form-voltage-activated-and-calcium-activated-calcium-channels.aspx Persons Quenton Hurst